Robert M. Hoffman

Gene expression profiling predicts clinical outcome of prostate cancer.

In vivo imaging with fluorescent proteins: the new cell biology.

Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells.

Protein carboxyl amidation increases the potential extent of protein polyethylene glycol conjugation.

Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression.

Homogeneous enzymatic colorimetric assay for total cysteine.

Oral 5-FU is a more effective antimetastatic agent than UFT.

Circulating half-life of PEGylated recombinant methioninase holoenzyme is highly dose dependent on cofactor pyridoxal-5'-phosphate.

3-Deazaadenosine, a stabilizer of whole-blood homocysteine content, does not interfere with the single-enzyme homocysteine assay while totally inhibiting the enzyme conversion homocysteine immunoassay.

Nascent blood vessels in the skin arise from nestin-expressing hair-follicle cells.

PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates.

Real-time whole-body imaging of an orthotopic metastatic prostate cancer model expressing red fluorescent protein.

Gene and stem cell therapy of the hair follicle.

Development of a green fluorescent protein metastatic-cancer chick-embryo drug-screen model.

Imaging tumor angiogenesis with fluorescent proteins.

Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors.

Direct evidence that PTHrP expression promotes prostate cancer progression in bone.

Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium.

Visualizing portal vein metastatic trafficking to the liver with green fluorescent protein-expressing tumor cells.

Color coding cancer cells with fluorescent proteins to visualize in vivo cellular interaction in metastatic colonies.

Hair follicle-derived blood vessels vascularize tumors in skin and are inhibited by Doxorubicin.

Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells.

Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons.

A rapid HPLC method for the measurement of ultra-low plasma methionine concentrations applicable to methionine depletion therapy.

Real-time in vivo dual-color imaging of intracapillary cancer cell and nucleus deformation and migration.

Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy.

Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis.

Dual-color, whole-body imaging in mice.

High-level expression and bulk crystallization of recombinant L-methionine gamma-lyase, an anticancer agent.

Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma.

Facile whole-body imaging of internal fluorescent tumors in mice with an LED flashlight.

Advantages of multi-color fluorescent proteins for whole-body and in vivo cellular imaging.

The multiple uses of fluorescent proteins to visualize cancer in vivo.

High correlation of whole-body red fluorescent protein imaging and magnetic resonance imaging on an orthotopic model of pancreatic cancer.

Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves.

In vivo cell biology of cancer cells visualized with fluorescent proteins.

Dual-color-coded imaging of viable circulating prostate carcinoma cells reveals genetic exchange between tumor cells in vivo, contributing to highly metastatic phenotypes.

Follicular penetration and targeting.

Dual-color imaging of nuclear-cytoplasmic dynamics, viability, and proliferation of cancer cells in the portal vein area.

The pluripotency of hair follicle stem cells.

Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds.

Dual-color imaging of nascent blood vessels vascularizing pancreatic cancer in an orthotopic model demonstrates antiangiogenesis efficacy of gemcitabine.

Physicochemical and pharmacokinetic characterization of highly potent recombinant L-methionine gamma-lyase conjugated with polyethylene glycol as an antitumor agent.

Common bile duct injection as a novel method for establishing red fluorescent protein (RFP)-expressing human pancreatic cancer in nude mice.

Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system.

The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model.

The hair follicle and its stem cells as drug delivery targets.

Tumor cells genetically labeled with GFP in the nucleus and RFP in the cytoplasm for imaging cellular dynamics.

Chemotherapy targets the hair-follicle vascular network but not the stem cells.

Visualization of xenotransplanted human rhabdomyosarcoma after transfection with red fluorescent protein.

Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice.

Real-time subcellular imaging in live animals: new visible targets for cancer drug discovery.

Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer.

Dual-color imaging of nascent angiogenesis and its inhibition in liver metastases of pancreatic cancer.

Visualization of nascent tumor angiogenesis in lung and liver metastasis by differential dual-color fluorescence imaging in nestin-linked-GFP mice.

In vivo color-coded imaging of the interaction of colon cancer cells and splenocytes in the formation of liver metastases.

Biomimetic amplification of nanoparticle homing to tumors.

In vitro photodynamic therapy of childhood rhabdomyosarcoma.

Noninvasive imaging for evaluation of the systemic delivery of capsid-modified adenovirus in an orthotopic model of advanced lung cancer.

Structure of the antitumour enzyme L-methionine gamma-lyase from Pseudomonas putida at 1.8 A resolution.

The potential of nestin-expressing hair follicle stem cells in regenerative medicine.

GFP-expressing vascularization of Gelfoam as a rapid in vivo assay of angiogenesis stimulators and inhibitors.

Subcellular imaging in the live mouse.

Color-coded fluorescence imaging of tumor-host interactions.

Whole-body imaging with fluorescent proteins.

Whole-body imaging of bacterial infection and antibiotic response.

Dual-color imaging of angiogenesis and its inhibition in bone and soft tissue sarcoma.

The camptothecin derivative CPT-11 inhibits angiogenesis in a dual-color imageable orthotopic metastatic nude mouse model of human colon cancer.

Whole-body subcellular multicolor imaging of tumor-host interaction and drug response in real time.

Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer.

Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model.

An imageable metastatic treatment model of nasopharyngeal carcinoma.

A novel alkylating agent, glufosfamide, enhances the activity of gemcitabine in vitro and in vivo.

Real-time imaging of tumor-cell shedding and trafficking in lymphatic channels.

Imaging of nucleolar dynamics during the cell cycle of cancer cells in live mice.

Characterization of HCT116 human colon cancer cells in an orthotopic model.

A better fluorescent protein for whole-body imaging.

Recent advances on in vivo imaging with fluorescent proteins.

Induction of cancer metastasis by cyclophosphamide pretreatment of host mice: an opposite effect of chemotherapy.

Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.

Imaging of primary and metastatic pancreatic cancer using a fluorophore-conjugated anti-CA19-9 antibody for surgical navigation.

Subcellular imaging of cancer cells in live mice.

The use of transgenic fluorescent mouse strains, fluorescent protein coding vectors, and innovative imaging techniques in the life sciences.

Salmonella promoters preferentially activated inside tumors.

Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function.

Fluorescent LYVE-1 antibody to image dynamically lymphatic trafficking of cancer cells in vivo.

Fluorophore-conjugated anti-CEA antibody for the intraoperative imaging of pancreatic and colorectal cancer.

In vivo fluorescence of medullary carcinoma of the thyroid: a technology with potential to improve visualization of malignant tissue at surgical resection.

A highly sensitive single-enzyme homocysteine assay.

Color-coded imaging of splenocyte-pancreatic cancer cell interactions in the tumor microenvironment.

Imaging cancer dynamics in vivo at the tumor and cellular level with fluorescent proteins.

In vivo real-time imaging of nuclear-cytoplasmic dynamics of dormancy, proliferation and death of cancer cells.

Real-time in vivo green fluorescent protein imaging of a murine leishmaniasis model as a new tool for Leishmania vaccine and drug discovery.

Enzymatic assay for total plasma Cys.

Nonradioactive enzymatic assay for plasma and serum vitamin B(6).

In vitro/in vivo biorecognition of lectin-immobilized fluorescent nanospheres for human colorectal cancer cells.

Chapter 2. Color-coded fluorescent mouse models of cancer cell interactions with blood vessels and lymphatics.

Human tumor growth in nude mice is associated with decreased plasma cysteine and homocysteine.

A transgenic red fluorescent protein-expressing nude mouse for color-coded imaging of the tumor microenvironment.

Human and mouse hair follicles contain both multipotent and monopotent stem cells.

Color-coded fluorescent protein imaging of angiogenesis: the AngioMouse models.

Comment re: Preclinical model of spontaneous melanoma metastasis.

Cancer metastasis directly eradicated by targeted therapy with a modified Salmonella typhimurium.

Multipotent nestin-expressing hair follicle stem cells.

Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium.

The cyan fluorescent protein (CFP) transgenic mouse as a model for imaging pancreatic exocrine cells.

Tumor-targeting amino acid auxotrophic Salmonella typhimurium.

Development of the transgenic cyan fluorescent protein (CFP)-expressing nude mouse for "Technicolor" cancer imaging.

Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging.

Effect of verapamil on the expression of EGFR and NM23 in A549 human lung cancer cells.

The stem cell mobilizer StemEnhance does not promote tumor growth in an orthotopic model of human breast cancer.

Complementarity of ultrasound and fluorescence imaging in an orthotopic mouse model of pancreatic cancer.

Dual-color imaging of tumor angiogenesis.

Extended-working-distance multiphoton micromanipulation microscope for deep-penetration imaging in live mice and tissue.

CXC-chemokine/CXCR2 biological axis promotes angiogenesis in vitro and in vivo in pancreatic cancer.

Human hair follicle pluripotent stem (hfPS) cells promote regeneration of peripheral-nerve injury: an advantageous alternative to ES and iPS cells.

Efficacy of a genetically-modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice.

Upregulation of thrombospondin-1 and angiogenesis in an aggressive human pancreatic cancer cell line selected for high metastasis.

Lentivirus-based DsRed-2-transfected pancreatic cancer cells for deep in vivo imaging of metastatic disease.

Efficacy of dietary antioxidants combined with a chemotherapeutic agent on human colon cancer progression in a fluorescent orthotopic mouse model.

In vivo gene transfer between interacting human osteosarcoma cell lines is associated with acquisition of enhanced metastatic potential.

In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation.

Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1.

Monotherapy with a tumor-targeting mutant of S. typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer.

Low-dose metronomic cyclophosphamide combined with vascular disrupting therapy induces potent antitumor activity in preclinical human tumor xenograft models.

The role of the intravascular microenvironment in spontaneous metastasis development.

Complementary use of fluorescence and magnetic resonance imaging of metastatic esophageal cancer in a novel orthotopic mouse model.

Selective metastatic tumor labeling with green fluorescent protein and killing by systemic administration of telomerase-dependent adenoviruses.

Isolation and culture of hair follicle pluripotent stem (hfPS) cells and their use for nerve and spinal cord regeneration.

Real-time imaging of single cancer-cell dynamics of lung metastasis.

Color-coded real-time cellular imaging of lung T-lymphocyte accumulation and focus formation in a mouse asthma model.

Detection of early colorectal cancer imaged with peanut agglutinin-immobilized fluorescent nanospheres having surface poly(N-vinylacetamide) chains.

Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers.

Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF.

Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-alpha-reductase inhibitor: a treatment strategy for acne.

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

Nestin-expressing interfollicular blood vessel network contributes to skin transplant survival and wound healing.

High-throughput screening for salmonella avirulent mutants that retain targeting of solid tumors.

Human breast cancer cell lines co-express neuronal, epithelial, and melanocytic differentiation markers in vitro and in vivo.

The combination of 5-FU, leucovorin and CPT-11 (FOLFIRI) prolongs survival through inhibition of metastasis in an orthotopic model of colon cancer.

Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro.

Mobilization of bone marrow stem cells with StemEnhance improves muscle regeneration in cardiotoxin-induced muscle injury.

Direct transplantation of uncultured hair-follicle pluripotent stem (hfPS) cells promotes the recovery of peripheral nerve injury.

UV light killing efficacy of fluorescent protein-expressing cancer cells in vitro and in vivo.

Broad selective efficacy of recombinant methioninase and polyethylene glycol-modified recombinant methioninase on cancer cells In Vitro.

Fluorescence laparoscopy imaging of pancreatic tumor progression in an orthotopic mouse model.

Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected].

Advances in cellular, subcellular, and nanoscale imaging in vitro and in vivo.

Magnetic resonance and fluorescence imaging of doxorubicin-loaded nanoparticles using a novel in vivo model.

Effective therapeutic targeting of the overexpressed HER-2 receptor in a highly metastatic orthotopic model of esophageal carcinoma.

Metronomic gemcitabine in combination with sunitinib inhibits multisite metastasis and increases survival in an orthotopic model of pancreatic cancer.

Simultaneous color-coded imaging to distinguish cancer "stem-like" and non-stem cells in the same tumor.

Embryonic development of hair follicle pluripotent stem (hfPS) cells.

High antimetastatic efficacy of MEN4901/T-0128, a novel camptothecin carboxymethyldextran conjugate.

Marker expression in circulating cancer cells of pancreatic cancer patients.

GFP-fluorescence-guided UVC irradiation inhibits melanoma growth and angiogenesis in nude mice.

The advantages of hair follicle pluripotent stem cells over embryonic stem cells and induced pluripotent stem cells for regenerative medicine.

Real-time imaging of tumor progression in a fluorescent orthotopic mouse model of thyroid cancer.

Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity.

Nestin-driven green fluorescent protein as an imaging marker for nascent blood vessels in mouse models of cancer.

A clinically relevant, syngeneic model of spontaneous, highly metastatic B16 mouse melanoma.

Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer.

Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging.

Long-working-distance fluorescence microscope with high-numerical-aperture objectives for variable-magnification imaging in live mice from macro- to subcellular.

Selective advantage of resistant strains at trace levels of antibiotics: a simple and ultrasensitive color test for detection of antibiotics and genotoxic agents.

Transdifferentiation of glioblastoma cells into vascular endothelial cells.

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling.

Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer.

The bulge area is the major hair follicle source of nestin-expressing pluripotent stem cells which can repair the spinal cord compared to the dermal papilla.

Characterization of nerve conduits seeded with neurons and Schwann cells derived from hair follicle neural crest stem cells.

Tumor imaging with multicolor fluorescent protein expression.

Magnetic resonance and fluorescence-protein imaging of the anti-angiogenic and anti-tumor efficacy of selenium in an orthotopic model of human colon cancer.

The bulge area is the origin of nestin-expressing pluripotent stem cells of the hair follicle.

Knockdown of the β(1) integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis.

Tumor-seeking Salmonella amino acid auxotrophs.

Watching stem cells in the skin of living mice noninvasively.

Time-course imaging of therapeutic functional tumor vascular normalization by antiangiogenic agents.

Circulating human prostate cancer cells from an orthotopic mouse model rapidly captured by immunomagnetic beads and imaged by GFP expression.

Lectin-immobilized fluorescent nanospheres for targeting to colorectal cancer from a physicochemical perspective.

Submillimeter-resolution fluorescence laparoscopy of pancreatic cancer in a carcinomatosis mouse model visualizes metastases not seen with standard laparoscopy.

Imaging of the interaction of cancer cells and the lymphatic system.

Stem-like and non-stem human pancreatic cancer cells distinguished by morphology and metastatic behavior.

Tumor-selective, adenoviral-mediated GFP genetic labeling of human cancer in the live mouse reports future recurrence after resection.

Comparison of μCT, MRI and optical reflectance imaging for assessing the growth of GFP/RFP-expressing tumors.

Development of new spontaneous metastatic heterotopic model of lewis lung carcinoma imaged by GFP expression.

In vivo imaging of nuclear-cytoplasmic deformation and partition during cancer cell death due to immune rejection.

A rapid imageable in vivo metastasis assay for circulating tumor cells.

HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers.

Tail spontaneous metastatic mouse model: comparison of metastatic potential of orthotopic and heterotopic models imaged by GFP and RFP protein.

Nestin-positive hair follicle pluripotent stem cells can promote regeneration of impinged peripheral nerve injury.

Comparison of cancer-cell seeding, viability and deformation in the lung, muscle and liver, visualized by subcellular real-time imaging in the live mouse.

Glowing tumors make for better detection and resection.

Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetent mice.

The cyan fluorescent protein nude mouse as a host for multicolor-coded imaging models of primary and metastatic tumor microenvironments.

Color-coded real-time subcellular fluorescence imaging of the interaction between cancer and host cells in live mice.

Cellular and Subcellular Imaging in Live Mice Using Fluorescent Proteins.

Fluorescence lifetime microscopy of tumor cell invasion, drug delivery, and cytotoxicity.

Inhibition and eradication of human glioma with tumor-targeting Salmonella typhimurium in an orthotopic nude-mouse model.

Imaging the inhibition of anti-β1 integrin antibody on lung seeding of single cells in live mice.

Detection of colon cancer metastases with fluorescence laparoscopy in orthotopic nude mouse models.

Fluorescent proteins enhance UVC PDT of cancer cells.

Cancer-cell killing by engineered Salmonella imaged by multiphoton tomography in live mice.

Fluorescence-guided surgery of human colon cancer increases complete resection resulting in cures in an orthotopic nude mouse model.

Involvement of CXCR4 chemokine receptor in metastastic HER2-positive esophageal cancer.

Fluorescent proteins as visible in vivo sensors.

Primer dosing of S. typhimurium A1-R potentiates tumor-targeting and efficacy in immunocompetent mice.

Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice.

Enhanced resection of orthotopic red-fluorescent-protein-expressing human glioma by fluorescence-guided surgery in nude mice.

VEGF-C ShRNA inhibits pancreatic cancer growth and lymphangiogenesis in an orthotopic fluorescent nude mouse model.

Intraoperative imaging of metastatic lymph nodes using a fluorophore-conjugated antibody in a HER2/neu-expressing orthotopic breast cancer mouse model.

The role of hair follicle nestin-expressing stem cells during whisker sensory-nerve growth in long-term 3D culture.

Specific route mapping visualized with GFP of single-file streaming contralateral and systemic metastasis of Lewis lung carcinoma cells beginning within hours of orthotopic implantation [correction of implantion].

Progression-free survival is accurately predicted in patients treated with chemotherapy for epithelial ovarian cancer by the histoculture drug response assay in a prospective correlative clinical trial at a single institution.

Fluorescence-guided surgery and fluorescence laparoscopy for gastrointestinal cancers in clinically-relevant mouse models.

Efficacy comparison of traditional Chinese medicine LQ versus gemcitabine in a mouse model of pancreatic cancer.

A color-coded imaging model of the interaction of αv integrin-GFP expressed in osteosarcoma cells and RFP expressing blood vessels in Gelfoam® vascularized in vivo.

Dynamic subcellular imaging of cancer cell mitosis in the brain of live mice.

Single cell time-lapse imaging of focus formation by the DNA damage-response protein 53BP1 after UVC irradiation of human pancreatic cancer cells.

In vivo serial selection of human pancreatic cancer cells in orthotopic mouse models produces high metastatic variants irrespective of Kras status.

Paclitaxel nanosuspensions for targeted chemotherapy - nanosuspension preparation, characterization, and use.

Salmonella typhimurium A1-R tumor targeting in immunocompetent mice is enhanced by a traditional Chinese medicine herbal mixture.

A dual-color genetically engineered mouse model for multispectral imaging of the pancreatic microenvironment.

Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy.

Ovarian tumor attachment, invasion, and vascularization reflect unique microenvironments in the peritoneum: insights from xenograft and mathematical models.

Imaging UVC-induced DNA damage response in models of minimal cancer.

Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force.

Stromal-cell and cancer-cell exosomes leading the metastatic exodus for the promised niche.

Tumor growth control with IDO-silencing Salmonella--letter.

Nestin-Expressing Stem Cells Promote Nerve Growth in Long-Term 3-Dimensional Gelfoam®-Supported Histoculture.

Real-time imaging of αv integrin molecular dynamics in osteosarcoma cells in vitro and in vivo.

Color-coded imaging of spontaneous vessel anastomosis in vivo.

In vivo fluorescence imaging reveals the promotion of mammary tumorigenesis by mesenchymal stromal cells.

In vivo fluorescence imaging of gastrointestinal stromal tumors using fluorophore-conjugated anti-KIT antibody.

Comparison of efficacy of Salmonella typhimurium A1-R and chemotherapy on stem-like and non-stem human pancreatic cancer cells.

Nestin-expressing stem cells from the hair follicle can differentiate into motor neurons and reduce muscle atrophy after transplantation to injured nerves.

High lung-metastatic variant of human osteosarcoma cells, selected by passage of lung metastasis in nude mice, is associated with increased expression of α(v)β(3) integrin.

A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells in S/G2/M phases.

Imageable clinically relevant mouse models of metastasis.

Imaging metastatic cell trafficking at the cellular level in vivo with fluorescent proteins.

Color-coded fluorescence imaging of lymph-node metastasis, angiogenesis, and its drug-induced inhibition.

Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling.

Imaging nuclear - cytoplasm dynamics of cancer cells in the intravascular niche of live mice.

Comparison of nestin-expressing multipotent stem cells in the tongue fungiform papilla and vibrissa hair follicle.

Fluorescently labeled chimeric anti-CEA antibody improves detection and resection of human colon cancer in a patient-derived orthotopic xenograft (PDOX) nude mouse model.

Development of a clinically-precise mouse model of rectal cancer.

Comparison of a chimeric anti-carcinoembryonic antigen antibody conjugated with visible or near-infrared fluorescent dyes for imaging pancreatic cancer in orthotopic nude mouse models.

Hand-held high-resolution fluorescence imaging system for fluorescence-guided surgery of patient and cell-line pancreatic tumors growing orthotopically in nude mice.

Efficacy of Salmonella typhimurium A1-R versus chemotherapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX).

Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer.

Parathyroid hormone related-protein promotes epithelial-to-mesenchymal transition in prostate cancer.

Successful fluorescence-guided surgery on human colon cancer patient-derived orthotopic xenograft mouse models using a fluorophore-conjugated anti-CEA antibody and a portable imaging system.

3-dimensional tissue is formed from cancer cells in vitro on Gelfoam®, but not on Matrigel™.

Fluorescence-guided surgery with a fluorophore-conjugated antibody to carcinoembryonic antigen (CEA), that highlights the tumor, improves surgical resection and increases survival in orthotopic mouse models of human pancreatic cancer.

Fluorescent angiogenesis models using gelfoam® implanted in transgenic mice expressing fluorescent proteins.

Invading cancer cells are predominantly in G0/G1 resulting in chemoresistance demonstrated by real-time FUCCI imaging.

Osteosarcoma cells enhance angiogenesis visualized by color-coded imaging in the in vivo Gelfoam® assay.

Advantages of fluorescence-guided laparoscopic surgery of pancreatic cancer labeled with fluorescent anti-carcinoembryonic antigen antibodies in an orthotopic mouse model.

Spatial-temporal FUCCI imaging of each cell in a tumor demonstrates locational dependence of cell cycle dynamics and chemoresponsiveness.

Comparison of UVB and UVC effects on the DNA damage-response protein 53BP1 in human pancreatic cancer.

Overactivated neddylation pathway as a therapeutic target in lung cancer.

Polyethylene glycol (PEG) linked to near infrared (NIR) dyes conjugated to chimeric anti-carcinoembryonic antigen (CEA) antibody enhances imaging of liver metastases in a nude-mouse model of human colon cancer.

Specific tumor labeling enhanced by polyethylene glycol linkage of near infrared dyes conjugated to a chimeric anti-carcinoembryonic antigen antibody in a nude mouse model of human pancreatic cancer.

Efficacy of tumor-targeting Salmonella typhimurium A1-R on nude mouse models of metastatic and disseminated human ovarian cancer.

Fluorescence-guided surgery in combination with UVC irradiation cures metastatic human pancreatic cancer in orthotopic mouse models.

Methods for the development of tumor-targeting bacteria.

Fluorescence-guided surgery of prostate cancer bone metastasis.

Specificity of lectin-immobilized fluorescent nanospheres for colorectal tumors in a mouse model which better resembles the clinical disease.

Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis.

Transgenic nude mice ubiquitously expressing fluorescent proteins for color-coded imaging of the tumor microenvironment.

The tumor-educated-macrophage increase of malignancy of human pancreatic cancer is prevented by zoledronic acid.

Fluorescence-guided surgery improves outcome in an orthotopic osteosarcoma nude-mouse model.

In vitro culture and characterization of human lung cancer circulating tumor cells isolated by size exclusion from an orthotopic nude-mouse model expressing fluorescent protein.

Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice.

Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity.

Comparison of efficacy and toxicity of traditional Chinese medicine (TCM) herbal mixture LQ and conventional chemotherapy on lung cancer metastasis and survival in mouse models.

Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models.

Circulating tumour cells go green.

Selective efficacy of zoledronic acid on metastasis in a patient-derived orthotopic xenograph (PDOX) nude-mouse model of human pancreatic cancer.

Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models.

Orthotopic mouse models of tumor metastasis expressing fluorescent reporters produce imageable circulating tumor cells.

Real-time fluorescence imaging of the DNA damage repair response during mitosis.

Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey.

Metastatic recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) nude mouse model is inhibited by neoadjuvant chemotherapy in combination with fluorescence-guided surgery with an anti-CA 19-9-conjugated fluorophore.

Tumor-targeting Salmonella typhimurium A1-R decoys quiescent cancer cells to cycle as visualized by FUCCI imaging and become sensitive to chemotherapy.

Independence of cytotoxic drug sensitivity profiles and receptor subtype of invasive ductal breast carcinoma demonstrated by the histoculture drug response assay (HDRA).

Biological ablation of sentinel lymph node metastasis in submucosally invaded early gastrointestinal cancer.

Inhibition of spontaneous and experimental lung metastasis of soft-tissue sarcoma by tumor-targeting Salmonella typhimurium A1-R.

Cell-cycle fate-monitoring distinguishes individual chemosensitive and chemoresistant cancer cells in drug-treated heterogeneous populations demonstrated by real-time FUCCI imaging.

Cancer cells mimic in vivo spatial-temporal cell-cycle phase distribution and chemosensitivity in 3-dimensional Gelfoam® histoculture but not 2-dimensional culture as visualized with real-time FUCCI imaging.

Tumor-targeting Salmonella typhimurium A1-R arrests growth of breast-cancer brain metastasis.

Tumor imaging technologies in mouse models.

Complementarity of variable-magnification and spectral-separation fluorescence imaging systems for noninvasive detection of metastasis and intravital detection of single cancer cells in mouse models.

Patient-derived orthotopic xenograft (PDOX) nude mouse model of soft-tissue sarcoma more closely mimics the patient behavior in contrast to the subcutaneous ectopic model.

Application of GFP imaging in cancer.

Establishment of a patient-derived orthotopic Xenograft (PDOX) model of HER-2-positive cervical cancer expressing the clinical metastatic pattern.

Fluorescence-guided surgery: it is the cure that matters: in reply to Giorgakis and colleagues.

Fluorescence-guided surgery of retroperitoneal-implanted human fibrosarcoma in nude mice delays or eliminates tumor recurrence and increases survival compared to bright-light surgery.

Comparison of the selective targeting efficacy of Salmonella typhimurium A1-R and VNP20009 on the Lewis lung carcinoma in nude mice.

Cryopreservation of the Hair Follicle Maintains Pluripotency of Nestin-Expressing Hair Follicle-Associated Pluripotent Stem Cells.

Nestin-expressing hair follicle-accessible pluripotent stem cells for nerve and spinal cord repair.

Traditional Chinese medicine herbal mixture LQ arrests FUCCI-expressing HeLa cells in G₀/G₁ phase in 2D plastic, 2.5D Matrigel, and 3D Gelfoam culture visualized with FUCCI imaging.

Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer.

Near infra-red photoimmunotherapy with anti-CEA-IR700 results in extensive tumor lysis and a significant decrease in tumor burden in orthotopic mouse models of pancreatic cancer.

Photoimmunotherapy lowers recurrence after pancreatic cancer surgery in orthotopic nude mouse models.

Fluorescence-guided surgery, but not bright-light surgery, prevents local recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) model resistant to neoadjuvant chemotherapy (NAC).

MUC1 selectively targets human pancreatic cancer in orthotopic nude mouse models.

Nanoparticle albumin-bound-paclitaxel: a limited improvement under the current therapeutic paradigm of pancreatic cancer.

Photoimmunotherapy Inhibits Tumor Recurrence After Surgical Resection on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model.

Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus.

Heterogeneous cell-cycle behavior in response to UVB irradiation by a population of single cancer cells visualized by time-lapse FUCCI imaging.

Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice.

Early Reporting of Apoptosis by Real-time Imaging of Cancer Cells Labeled with Green Fluorescent Protein in the Nucleus and Red Fluorescent Protein in the Cytoplasm.

Imaging the Interaction of Pancreatic Cancer and Stellate Cells in the Tumor Microenvironment during Metastasis.

The Use of Living Cancer Cells Expressing Green Fluorescent Protein in the Nucleus and Red Fluorescence Protein in the Cytoplasm for Real-time Confocal Imaging of Chromosome and Cytoplasmic Dynamics During Mitosis.

From hair to heart: nestin-expressing hair-follicle-associated pluripotent (HAP) stem cells differentiate to beating cardiac muscle cells.

Color-Coded Imaging of Breast Cancer Metastatic Niche Formation in Nude Mice.

Drug exposure in a metastatic human lung adenocarcinoma cell line gives rise to cells with differing adhesion, proliferation, and gene expression: Implications for cancer chemotherapy.

Combination Efficacy of Astragalus membranaceus and Curcuma wenyujin at Different Stages of Tumor Progression in an Imageable Orthotopic Nude Mouse Model of Metastatic Human Ovarian Cancer Expressing Red Fluorescent Protein.

Targeting tumors with a killer-reporter adenovirus for curative fluorescence-guided surgery of soft-tissue sarcoma.

Tumor-Targeting Salmonella typhimurium A1-R in Combination with Trastuzumab Eradicates HER-2-Positive Cervical Cancer Cells in Patient-Derived Mouse Models.

Back to the Future: Are Tumor-Targeting Bacteria the Next-Generation Cancer Therapy?

Real-time Non-invasive Spectral Imaging of Orthotopic Red Fluorescent Protein-expressing Lung Tumor Growth in Nude Mice.

Fluorescence-guided surgery of human prostate cancer experimental bone metastasis in nude mice using anti-CEA DyLight 650 for tumor illumination.

Tumor-Targeting Salmonella typhimurium A1-R Arrests a Chemo-Resistant Patient Soft-Tissue Sarcoma in Nude Mice.

Long-Term Extensive Ectopic Hair Growth on the Spinal Cord of Mice from Transplanted Whisker Follicles.

Surgically-Induced Multi-organ Metastasis in an Orthotopic Syngeneic Imageable Model of 4T1 Murine Breast Cancer.

A Color-coded Imageable Syngeneic Mouse Model of Stromal-cell Recruitment by Metastatic Lymphoma.

Comparison of GFP-Expressing Imageable Mouse Models of Human Esophageal Squamous Cell Carcinoma Established in Various Anatomical Sites.

Improved disease-free survival and overall survival after fluorescence-guided surgery of liver metastasis in an orthotopic nude mouse model.

Therapeutic efficacy of tumor-targeting Salmonella typhimurium A1-R on human colorectal cancer liver metastasis in orthotopic nude-mouse models.

Precise navigation surgery of tumours in the lung in mouse models enabled by in situ fluorescence labelling with a killer-reporter adenovirus.

Comparison of label-free and GFP multiphoton imaging of hair follicle-associated pluripotent (HAP) stem cells in mouse whiskers.

Imaging the Different Mechanisms of Prostate Cancer Cell-killing by Tumor-targeting Salmonella typhimurium A1-R.

Extensive Hair-Shaft Elongation by Isolated Mouse Whisker Follicles in Very Long-Term Gelfoam® Histoculture.

Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts.

Fluorescence-Guided Surgery of Liver Metastasis in Orthotopic Nude-Mouse Models.

Tumor-targeting Salmonella typhimurium A1-R inhibits human prostate cancer experimental bone metastasis in mouse models.

Eradication of osteosarcoma by fluorescence-guided surgery with tumor labeling by a killer-reporter adenovirus.

Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model.

Recruitment of Cancer-Associated Fibroblasts and Blood Vessels by Orthotopic Liver Tumors Imaged in Red Fluorescent Protein (RFP) Transgenic Nude Mice.

Real Time Metastatic Route Tracking of Orthotopic PC-3-GFP Human Prostate Cancer Using Intravital Imaging.

Prostate Cancer Heterogeneous High-Metastatic Multi-Organ-Colonizing Chemo-Resistant Variants Selected by Serial Metastatic Passage in Nude Mice Are Highly Enriched for Multinucleate Giant Cells.

Current status and future perspectives of fluorescence-guided surgery for cancer.

Adenoviral targeting of malignant melanoma for fluorescence-guided surgery prevents recurrence in orthotopic nude-mouse models.

Extensive Hair Shaft Growth after Mouse Whisker Follicle Isolation, Cryopreservation and Transplantation in Nude Mice.

Fluorescent-Antibody Targeting of Insulin-Like Growth Factor-1 Receptor Visualizes Metastatic Human Colon Cancer in Orthotopic Mouse Models.

Imaging the microenvironment of pancreatic cancer patient-derived orthotopic xenografts (PDOX) growing in transgenic nude mice expressing GFP, RFP, or CFP.

Analysis of Two Complementary Single-Gene Deletion Mutant Libraries of Salmonella Typhimurium in Intraperitoneal Infection of BALB/c Mice.

Tumor-Targeting Salmonella typhimurium A1-R: An Overview.

Methods for Tumor Targeting with Salmonella typhimurium A1-R.

Salmonella typhimurium A1-R and Cell-Cycle Decoy Therapy of Cancer.

Future of Bacterial Therapy of Cancer.

Improved Resection and Outcome of Colon-Cancer Liver Metastasis with Fluorescence-Guided Surgery Using In Situ GFP Labeling with a Telomerase-Dependent Adenovirus in an Orthotopic Mouse Model.

Surgical and Oncological Factors Affecting the Successful Engraftment of Patient-derived Xenografts in Pancreatic Ductal Adenocarcinoma.

Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model.

Toward Curative Fluorescence-Guided Surgery of Pancreatic Cancer.

Targeting the insulin growth factor-1 receptor with fluorescent antibodies enables high resolution imaging of human pancreatic cancer in orthotopic mouse models.

Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment.

Use of fluorescent proteins and color-coded imaging to visualize cancer cells with different genetic properties.

Decreased Expression of Tumor-suppressor Gene LKB1 Correlates with Poor Prognosis in Human Gastric Cancer.

Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells.

Real-Time In Vivo Confocal Fluorescence Imaging of Prostate Cancer Bone-Marrow Micrometastasis Development at the Cellular Level in Nude Mice.

Real-Time GFP Intravital Imaging of the Differences in Cellular and Angiogenic Behavior of Subcutaneous and Orthotopic Nude-Mouse Models of Human PC-3 Prostate Cancer.

Blockage of autophagy pathway enhances Salmonella tumor-targeting.

Color-Coded Imaging of Syngeneic Orthotopic Malignant Lymphoma Interacting with Host Stromal Cells During Metastasis.

Modified Liver Hanging Maneuver for En-bloc Right-sided Hepatectomy Combined with Total Caudate Lobectomy for Colon-Cancer Liver Metastasis and Hepatocellular Carcinoma.

Isoproterenol directs hair follicle-associated pluripotent (HAP) stem cells to differentiate in vitro to cardiac muscle cells which can be induced to form beating heart-muscle tissue sheets.

High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model.

Therapeutic Efficacy of the Traditional Chinese Medicine Baishaoqiwu on TNBS-induced Colitis is Associated with Down-regulation of the TLR4/MyD88/NF-κB Signaling Pathway.

Bone Marrow Mesenchymal Stem Cells Reverse Liver Damage in a Carbon Tetrachloride-induced Mouse Model of Chronic Liver Injury.

Imaging Nuclear-Cytoplasmic Dynamics in Primary and Metastatic Colon Cancer in Nude Mice.

Orthotopic Implantation of Intact Tumor Tissue Leads to Metastasis of OCUM-2MD3 Human Gastric Cancer in Nude Mice Visualized in Real Time by Intravital Fluorescence Imaging.

Solid tumors provide niche-specific conditions that lead to preferential growth of Salmonella.

Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging.

Therapeutic efficacy in vivo of a telomerase-dependent adenovirus in an orthotopic model of chemotherapy-resistant human stomach carcinomatosis peritonitis visualized with cell cycle color coding FUCCI imaging.

Use of αv integrin linked to GFP to image molecular dynamics in trafficking cancer-cell emboli.

siRNA Targeting of MDR1 Reverses Multidrug Resistance in a Nude Mouse Model of Doxorubicin-resistant Human Hepatocellular Carcinoma.

Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model.

Disintegrin targeting of an αvβ3 integrin-over-expressing high-metastatic human osteosarcoma with Echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro.

Labeling the Stroma of a Patient-Derived Orthotopic Xenograft (PDOX) Mouse Model of Undifferentiated Pleomorphic Soft-Tissue Sarcoma With Red Fluorescent Protein for Rapid Non-Invasive Imaging for Drug Screening.

Early-age-dependent selective decrease of differentiation potential of hair-follicle-associated pluripotent (HAP) stem cells to beating cardiac-muscle cells.

Introduction to Hair-Follicle-Associated Pluripotent Stem Cells.

Discovery of HAP Stem Cells.

Peripheral-Nerve and Spinal-Cord Regeneration in Mice Using Hair-Follicle-Associated Pluripotent (HAP) Stem Cells.

Nestin-Expressing Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Promote Whisker Sensory-Nerve Growth in Long-Term 3D-Gelfoam® Histoculture.

Protocols for Ectopic Hair Growth from Transplanted Whisker Follicles on the Spinal Cord of Mice.

Protocols for Gelfoam(®) Histoculture of Hair-Shaft-Producing Mouse Whisker Follicles Containing Nestin-GFP-Expressing Hair-Follicle-Associated Pluripotent (HAP) Stem Cells for Long Time Periods.

Protocols for Efficient Differentiation of Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Beating Cardiac Muscle Cells.

Protocols for Cryopreservation of Intact Hair Follicle That Maintain Pluripotency of Nestin-Expressing Hair-Follicle-Associated Pluripotent (HAP) Stem Cells.

Use of αv Integrin Linked to Green Fluorescent Protein in Osteosarcoma Cells and Confocal Microscopy to Image Molecular Dynamics During Lung Metastasis in Nude Mice.

In Vivo Isolation of a Highly-aggressive Variant of Triple-negative Human Breast Cancer MDA-MB-231 Using Serial Orthotopic Transplantation.

Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein.

Color-coded Live Imaging of Heterokaryon Formation and Nuclear Fusion of Hybridizing Cancer Cells.

Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium.

Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model.

Strategies for In Vivo Imaging Using Fluorescent Proteins.

A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts.

Enhanced Metastatic Recurrence via Lymphatic Trafficking of a High-Metastatic Variant of Human Triple-Negative Breast Cancer After Surgical Resection in Orthotopic Nude Mouse Models.

Hypoxia Enhances Differentiation of Hair Follicle-Associated-Pluripotent (HAP) Stem Cells to Cardiac Muscle Cells.