Department of Physiology and Biophysics
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Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2004 | Pubmed ID: 14715896
Cardiomyocyte-specific desmin rescue of desmin null cardiomyopathy excludes vascular involvement.
Journal of molecular and cellular cardiology Jan, 2004 | Pubmed ID: 14734054
Structural and functional roles of desmin in mouse skeletal muscle during passive deformation.
Biophysical journal May, 2004 | Pubmed ID: 15111414
Alterations in the heart mitochondrial proteome in a desmin null heart failure model.
Journal of molecular and cellular cardiology Mar, 2005 | Pubmed ID: 15733906
Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle.
Nature cell biology May, 2005 | Pubmed ID: 15834406
Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice.
Physiological genomics Sep, 2005 | Pubmed ID: 15998745
Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes.
Biophysical journal Jun, 2006 | Pubmed ID: 16565048
Ca2+ sparks as a plastic signal for skeletal muscle health, aging, and dystrophy.
Acta pharmacologica Sinica Jul, 2006 | Pubmed ID: 16787561
Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release.
The Journal of cell biology Aug, 2006 | Pubmed ID: 16943181
Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor.
The Journal of biological chemistry Nov, 2006 | Pubmed ID: 16945924
Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle.
Cell calcium Dec, 2007 | Pubmed ID: 17412417
Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans.
Journal of molecular and cellular cardiology Jun, 2007 | Pubmed ID: 17509612
TRIC channels are essential for Ca2+ handling in intracellular stores.
Nature Jul, 2007 | Pubmed ID: 17611541
The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis.
Journal of cell science Aug, 2007 | Pubmed ID: 17666431
Immuno-proteomic approach to excitation--contraction coupling in skeletal and cardiac muscle: molecular insights revealed by the mitsugumins.
Cell calcium Jan, 2008 | Pubmed ID: 18061662
Altered Ca2+ sparks in aging skeletal and cardiac muscle.
Ageing research reviews Jul, 2008 | Pubmed ID: 18272434
Caveolae/caveolin-1 are important modulators of store-operated calcium entry in Hs578/T breast cancer cells.
Journal of pharmacological sciences Feb, 2008 | Pubmed ID: 18296864
Compromised store-operated Ca2+ entry in aged skeletal muscle.
Aging cell Aug, 2008 | Pubmed ID: 18505477
A missense mutation in desmin tail domain linked to human dilated cardiomyopathy promotes cleavage of the head domain and abolishes its Z-disc localization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Sep, 2008 | Pubmed ID: 18539904
MG53 regulates membrane budding and exocytosis in muscle cells.
The Journal of biological chemistry Jan, 2009 | Pubmed ID: 19029292
MG53 nucleates assembly of cell membrane repair machinery.
Nature cell biology Jan, 2009 | Pubmed ID: 19043407
The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells.
American journal of physiology. Cell physiology Feb, 2009 | Pubmed ID: 19091958
Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin.
The Journal of biological chemistry Jun, 2009 | Pubmed ID: 19380584
Mitsugumin 53 (MG53) facilitates vesicle trafficking in striated muscle to contribute to cell membrane repair.
Communicative & integrative biology May, 2009 | Pubmed ID: 19641737
S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle.
The Biochemical journal Apr, 2010 | Pubmed ID: 20095964
Repression of cardiac phospholamban gene expression is mediated by thyroid hormone receptor-{alpha}1 and involves targeted covalent histone modifications.
Endocrinology Jun, 2010 | Pubmed ID: 20392835
Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair.
Circulation research Jul, 2010 | Pubmed ID: 20466981
MG53 constitutes a primary determinant of cardiac ischemic preconditioning.
Circulation Jun, 2010 | Pubmed ID: 20516375
Increased store-operated Ca2+ entry in skeletal muscle with reduced calsequestrin-1 expression.
Biophysical journal Sep, 2010 | Pubmed ID: 20816068
Amphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanisms.
The Journal of biological chemistry Mar, 2011 | Pubmed ID: 21189256
Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
Circulation. Heart failure Mar, 2011 | Pubmed ID: 21216834
Polymerase transcriptase release factor (PTRF) anchors MG53 protein to cell injury site for initiation of membrane repair.
The Journal of biological chemistry Apr, 2011 | Pubmed ID: 21343302
Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch.
Journal of neuropathology and experimental neurology Apr, 2011 | Pubmed ID: 21412170
A versatile single-plasmid system for tissue-specific and inducible control of gene expression in transgenic mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug, 2011 | Pubmed ID: 21518849
Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair.
American journal of physiology. Cell physiology Jul, 2011 | Pubmed ID: 21525429
Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals.
Cell research Sep, 2011 | Pubmed ID: 21556035
Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle.
Aging Jun, 2011 | Pubmed ID: 21666285
Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling.
The Journal of biological chemistry Sep, 2011 | Pubmed ID: 21795684
Disrupted membrane structure and intracellular Ca²⺠signaling in adult skeletal muscle with acute knockdown of Bin1.
PloS one , 2011 | Pubmed ID: 21984944
Store-operated calcium entry is present in HL-1 cardiomyocytes and contributes to resting calcium.
Biochemical and biophysical research communications Dec, 2011 | Pubmed ID: 22079292
Detection of calcium sparks in intact and permeabilized skeletal muscle fibers.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22130850
Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jan, 2012 | Pubmed ID: 22253476
Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in δ-Sarcoglycan-deficient Hamsters.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2012 | Pubmed ID: 22314291
Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy.
Science translational medicine Jun, 2012 | Pubmed ID: 22723464
Poloxamer 188 (p188) as a membrane resealing reagent in biomedical applications.
Recent patents on biotechnology Dec, 2012 | Pubmed ID: 23092436
Orai1 mediates exacerbated Ca(2+) entry in dystrophic skeletal muscle.
PloS one , 2012 | Pubmed ID: 23185465
Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.
The Journal of biological chemistry Jan, 2013 | Pubmed ID: 23223241
A dual mode pulsed electro-magnetic cell stimulator produces acceleration of myogenic differentiation.
Recent patents on biotechnology Apr, 2013 | Pubmed ID: 23445453
TRIM proteins in therapeutic membrane repair of muscular dystrophy.
JAMA neurology Jul, 2013 | Pubmed ID: 23699904
Novel excitation-contraction coupling related genes reveal aspects of muscle weakness beyond atrophy-new hopes for treatment of musculoskeletal diseases.
Frontiers in physiology , 2014 | Pubmed ID: 24600395
Ki Ho Park1,
Noah Weisleder2,
Jingsong Zhou3,
Kristyn Gumpper1,
Xinyu Zhou1,
Pu Duann4,
Jianjie Ma1,
Pei-Hui Lin1
1Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center,
2Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center,
3Department of Molecular Biophysics and Physiology, Rush University Medical Center,
4Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center
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