Francesco A. Aprile

Direct observation of the interconversion of normal and toxic forms of α-synuclein.

Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain.

NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain.

The CamSol method of rational design of protein mutants with enhanced solubility.

Structure of a low-population intermediate state in the release of an enzyme product.

Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms.

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate.

Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins.

Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis.

Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates.

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions.

Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.

Structure of a low-population binding intermediate in protein-RNA recognition.

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.

Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation.

Methods of probing the interactions between small molecules and disordered proteins.

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.

Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide.

The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases.

Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.

A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.

Cooperative Assembly of Hsp70 Subdomain Clusters.

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Author Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.

Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms.

Third generation antibody discovery methods: in silico rational design.