Centre for Misfolding Diseases,
Department of Chemistry,
Centre for Misfolding Diseases, Department of Chemistry
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Direct observation of the interconversion of normal and toxic forms of α-synuclein.
Cell May, 2012 | Pubmed ID: 22632969
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.
Journal of molecular biology Jul, 2013 | Pubmed ID: 23557833
Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain.
PloS one , 2013 | Pubmed ID: 23840795
NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain.
Protein science : a publication of the Protein Society Nov, 2014 | Pubmed ID: 25147050
The CamSol method of rational design of protein mutants with enhanced solubility.
Journal of molecular biology Jan, 2015 | Pubmed ID: 25451785
Structure of a low-population intermediate state in the release of an enzyme product.
eLife Jan, 2015 | Pubmed ID: 25575179
Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms.
Structure (London, England : 1993) Apr, 2015 | Pubmed ID: 25773142
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2015 | Pubmed ID: 25855634
A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate.
Biochemistry Aug, 2015 | Pubmed ID: 26192230
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2015 | Pubmed ID: 26216991
Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis.
FEBS letters Sep, 2015 | Pubmed ID: 26257049
Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates.
Chemical communications (Cambridge, England) Oct, 2015 | Pubmed ID: 26328629
Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions.
ACS nano Jan, 2016 | Pubmed ID: 26678709
Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.
Analytical chemistry Apr, 2016 | Pubmed ID: 26940224
Structure of a low-population binding intermediate in protein-RNA recognition.
Proceedings of the National Academy of Sciences of the United States of America 06, 2016 | Pubmed ID: 27286828
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.
Proceedings of the National Academy of Sciences of the United States of America 02, 2017 | Pubmed ID: 28096355
Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.
Biochemistry 03, 2017 | Pubmed ID: 28230968
Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation.
Molecular cell Mar, 2017 | Pubmed ID: 28306505
Methods of probing the interactions between small molecules and disordered proteins.
Cellular and molecular life sciences : CMLS 09, 2017 | Pubmed ID: 28631009
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.
Science advances Jun, 2017 | Pubmed ID: 28691099
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide.
Journal of molecular biology Sep, 2017 | Pubmed ID: 28743590
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.
Scientific reports Aug, 2017 | Pubmed ID: 28831037
A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases.
Chem Oct, 2017 | Pubmed ID: 29094109
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.
Scientific reports Nov, 2017 | Pubmed ID: 29118344
A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.
International journal of molecular sciences May, 2018 | Pubmed ID: 29757200
Cooperative Assembly of Hsp70 Subdomain Clusters.
Biochemistry Jul, 2018 | Pubmed ID: 29763298
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
ACS chemical biology Aug, 2018 | Pubmed ID: 29953201
Author Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.
Scientific reports Aug, 2018 | Pubmed ID: 30068912
Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms.
International journal of molecular sciences Sep, 2018 | Pubmed ID: 30205618
Third generation antibody discovery methods: in silico rational design.
Chemical Society reviews Oct, 2018 | Pubmed ID: 30298157
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