Michael Sendtner

Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?

Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult.

Association of a null mutation in the CNTF gene with early onset of multiple sclerosis.

Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene.

CNTF is a major protective factor in demyelinating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation.

Gene targeting of Gemin2 in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death.

The Gene for Ciliary Neurotrophic Factor (CNTF) Maps to Murine Chromosome 19 and its Expression is Not Affected in the Hereditary Motoneuron Disease 'Wobbler' of the Mouse.

Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches.

Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease.

A transgene carrying an A2G missense mutation in the SMN gene modulates phenotypic severity in mice with severe (type I) spinal muscular atrophy.

Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues.

Early onset of degenerative changes at nodes of Ranvier in alpha-motor axons of Cntf null (-/-) mutant mice.

Endogenous ciliary neurotrophic factor protects GABAergic, but not cholinergic, septohippocampal neurons following fimbria-fornix transection.

Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons.

Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites.

Axonal defects in mouse models of motoneuron disease.

The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E.

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development.

Characterization of Ighmbp2 in motor neurons and implications for the pathomechanism in a mouse model of human spinal muscular atrophy with respiratory distress type 1 (SMARD1).

Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor.

Optical assessment of motoneuron function in a "twenty-four-hour" acute spinal cord slice model from fetal rats.

Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation.

Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function.

Motoneuron survival after C7 nerve root avulsion and replantation in the adult rabbit: effects of local ciliary neurotrophic factor and brain-derived neurotrophic factor application.

Mechanisms of axonal degeneration in EAE--lessons from CNTF and MHC I knockout mice.

Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.

The role of neurotrophins in muscle under physiological and pathological conditions.

Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1.

Damaging secretions: chromogranins team up with mutant SOD1.

Distinct and overlapping alterations in motor and sensory neurons in a mouse model of spinal muscular atrophy.

Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla.

Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells.

High-efficiency gene transfer into cultured embryonic motoneurons using recombinant lentiviruses.

Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain.

Novel SOD1 N86K mutation is associated with a severe phenotype in familial ALS.

Large-scale pathways-based association study in amyotrophic lateral sclerosis.

The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis.

Differential modulation of neurite growth by the S- and the L-forms of bag1, a co-chaperone of Hsp70.

Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.

Defective Ca2+ channel clustering in axon terminals disturbs excitability in motoneurons in spinal muscular atrophy.

Haploinsufficiency of c-Met in cd44-/- mice identifies a collaboration of CD44 and c-Met in vivo.

Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB.

Leukemia inhibitory factor deficiency modulates the immune response and limits autoimmune demyelination: a new role for neurotrophic cytokines in neuroinflammation.

Single-dose application of CNTF and BDNF improves remyelination of regenerating nerve fibers after C7 ventral root avulsion and replantation.

Spiral ganglion outgrowth and hearing development in p75-deficient mice.

Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration.

Stem cells: Tailor-made diseased neurons.

Drosophila RSK negatively regulates bouton number at the neuromuscular junction.

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.

P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.

Valproic acid blocks excitability in SMA type I mouse motor neurons.

Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.

Progressive postnatal motoneuron loss in mice lacking GDF-15.

C-terminal FUS/TLS mutations in familial and sporadic ALS in Germany.

Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy.

Isolation and enrichment of embryonic mouse motoneurons from the lumbar spinal cord of individual mouse embryos.

Neuromuscular defects and breathing disorders in a new mouse model of spinal muscular atrophy.

Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth.

The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons.

Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta/delta mouse model of amyotrophic lateral sclerosis.

PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons.

Therapy development in spinal muscular atrophy.

Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis.

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease.

TDP-43: multiple targets, multiple disease mechanisms?

A new postal code for dendritic mRNA transport in neurons.

Regenerative medicine: Bespoke cells for the human brain.

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Therapeutic effects of PEGylated insulin-like growth factor I in the pmn mouse model of motoneuron disease.

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis.

Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts.

Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion.

Microtubule associated tumor suppressor 1 deficient mice develop spontaneous heart hypertrophy and SLE-like lymphoproliferative disease.