Ramasamy Paulmurugan

Molecular imaging of drug-modulated protein-protein interactions in living subjects.

Molecular imaging of homodimeric protein-protein interactions in living subjects.

Novel bidirectional vector strategy for amplification of therapeutic and reporter gene expression.

Firefly luciferase enzyme fragment complementation for imaging in cells and living animals.

Novel fusion protein approach for efficient high-throughput screening of small molecule-mediating protein-protein interactions in cells and living animals.

Visualization of telomerase reverse transcriptase (hTERT) promoter activity using a trimodality fusion reporter construct.

An intramolecular folding sensor for imaging estrogen receptor-ligand interactions.

Reporter gene imaging of protein-protein interactions in living subjects.

Combinatorial library screening for developing an improved split-firefly luciferase fragment-assisted complementation system for studying protein-protein interactions.

Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects.

US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice.

Monitoring of the biological response to murine hindlimb ischemia with 64Cu-labeled vascular endothelial growth factor-121 positron emission tomography.

A human estrogen receptor (ER)alpha mutation with differential responsiveness to nonsteroidal ligands: novel approaches for studying mechanism of ER action.

The death domain-containing kinase RIP1 regulates p27(Kip1) levels through the PI3K-Akt-forkhead pathway.

Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo.

Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation.

Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice.

Imaging gene expression in human mesenchymal stem cells: from small to large animals.

A novel estrogen receptor intramolecular folding-based titratable transgene expression system.

Noninvasive molecular imaging of c-Myc activation in living mice.

Imaging cellular receptors in breast cancers: an overview.

In vitro and in vivo molecular imaging of estrogen receptor α and β homo- and heterodimerization: exploration of new modes of receptor regulation.

Intratumoral versus intravenous gene therapy using a transcriptionally targeted viral vector in an orthotopic hepatocellular carcinoma rat model.

Cationic versus neutral microbubbles for ultrasound-mediated gene delivery in cancer.

Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.

Ultrasound-mediated gene delivery with cationic versus neutral microbubbles: effect of DNA and microbubble dose on in vivo transfection efficiency.

Real time dynamic imaging and current targeted therapies in the war on cancer: a new paradigm.

A c-Myc activation sensor-based high-throughput drug screening identifies an antineoplastic effect of nitazoxanide.

Reporter protein complementation imaging assay to screen and study Nrf2 activators in cells and living animals.

A titratable two-step transcriptional amplification strategy for targeted gene therapy based on ligand-induced intramolecular folding of a mutant human estrogen receptor.

Polymer nanoparticles for drug and small silencing RNA delivery to treat cancers of different phenotypes.

MicroRNAs - a new generation molecular targets for treating cellular diseases.

Therapeutic evaluation of microRNAs by molecular imaging.

Noninvasive theranostic imaging of HSV1-sr39TK-NTR/GCV-CB1954 dual-prodrug therapy in metastatic lung lesions of MDA-MB-231 triple negative breast cancer in mice.

Dynamic analysis of GH receptor conformational changes by split luciferase complementation.

Targeting SUMOylation cascade for diabetes management.

The emerging role of redox-sensitive Nrf2-Keap1 pathway in diabetes.

Degron protease blockade sensor to image epigenetic histone protein methylation in cells and living animals.

Genetically encoded molecular biosensors to image histone methylation in living animals.

Polymer nanoparticles mediated codelivery of antimiR-10b and antimiR-21 for achieving triple negative breast cancer therapy.

Core-shell upconversion nanoparticle - semiconductor heterostructures for photodynamic therapy.

Ultrasound-guided delivery of microRNA loaded nanoparticles into cancer.

Formulation of Anti-miR-21 and 4-Hydroxytamoxifen Co-loaded Biodegradable Polymer Nanoparticles and Their Antiproliferative Effect on Breast Cancer Cells.

Development of a High-Throughput Molecular Imaging-Based Orthotopic Hepatocellular Carcinoma Model.

Monitoring the Antioxidant Mediated Chemosensitization and ARE-Signaling in Triple Negative Breast Cancer Therapy.

Folate Receptor-Targeted Polymeric Micellar Nanocarriers for Delivery of Orlistat as a Repurposed Drug against Triple-Negative Breast Cancer.

Nanoparticle-Delivered Antisense MicroRNA-21 Enhances the Effects of Temozolomide on Glioblastoma Cells.

Pterostilbene Ameliorates Streptozotocin-Induced Diabetes through Enhancing Antioxidant Signaling Pathways Mediated by Nrf2.

Orlistat and antisense-miRNA-loaded PLGA-PEG nanoparticles for enhanced triple negative breast cancer therapy.

Noninvasive Monitoring of the Mitochondrial Function in Mesenchymal Stromal Cells.

Temozolomide-loaded PLGA nanoparticles to treat glioblastoma cells: a biophysical and cell culture evaluation.

GHR/PRLR Heteromultimer Is Composed of GHR Homodimers and PRLR Homodimers.

A molecular imaging biosensor detects in vivo protein folding and misfolding.

Imaging Histone Methylations in Living Animals.

Theranostic Imaging of Cancer Gene Therapy.

H-Penciclovir (H-PCV) Uptake Assay.

Ultrasound-guided therapeutic modulation of hepatocellular carcinoma using complementary microRNAs.

Tailored Nanoparticle Codelivery of antimiR-21 and antimiR-10b Augments Glioblastoma Cell Kill by Temozolomide: Toward a "Personalized" Anti-microRNA Therapy.

A transgenic mouse model expressing an ERα folding biosensor reveals the effects of Bisphenol A on estrogen receptor signaling.

Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells Under Flow.

Molecular Imaging Biosensor Monitors p53 Sumoylation in Cells and Living Mice.

A Model-Based Personalized Cancer Screening Strategy for Detecting Early-Stage Tumors Using Blood-Borne Biomarkers.

Engineering Intracellularly Retained Gaussia Luciferase Reporters for Improved Biosensing and Molecular Imaging Applications.

Cell membrane-coated nanocarriers: the emerging targeted delivery system for cancer theranostics.

Longitudinal assessment of ultrasound-guided complementary microRNA therapy of hepatocellular carcinoma.

Targeted nanoparticle delivery of therapeutic antisense microRNAs presensitizes glioblastoma cells to lower effective doses of temozolomide and in a mouse model.

A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells.

Restoring guardianship of the genome: Anticancer drug strategies to reverse oncogenic mutant p53 misfolding.

Comparison of cell-based assays to quantify treatment effects of anticancer drugs identifies a new application for Bodipy-L-cystine to measure apoptosis.

In vitro Determination of Rapamycin-triggered FKBP-FRB Interactions Using a Molecular Tension Probe.

Intracellular MicroRNA Quantification in Intact Cells: A Novel Strategy based on Reduced Graphene Oxide Based Fluorescence Quenching.

Near-Infrared Bioluminescence Imaging with a through-Bond Energy Transfer Cassette.

Molecular Imaging of Retinoic Acids in Live Cells Using Single-Chain Bioluminescence Probes.

The protean world of non-coding RNAs in glioblastoma.

Highly bright and stable NIR-BRET with blue-shifted coelenterazine derivatives for deep-tissue imaging of molecular events .

Cell-based biosensors: Recent trends, challenges and future perspectives.

Ultrasound/microbubble-mediated targeted delivery of anticancer microRNA-loaded nanoparticles to deep tissues in pigs.

Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide.

Microvesicle-Mediated Delivery of Minicircle DNA Results in Effective Gene-Directed Enzyme Prodrug Cancer Therapy.

Structural determination of Enzyme-Graphene Nanocomposite Sensor Material.

The Myocardial Microenvironment Modulates the Biology of Transplanted Mesenchymal Stem Cells.

Efficacy of Affibody-Based Ultrasound Molecular Imaging of Vascular B7-H3 for Breast Cancer Detection.

Ultrasound-mediated delivery of miRNA-122 and anti-miRNA-21 therapeutically immunomodulates murine hepatocellular carcinoma in vivo.

Assessment of Metastatic and Reactive Sentinel Lymph Nodes with B7-H3-Targeted Ultrasound Molecular Imaging: A Longitudinal Study in Mouse Models.

SP94-Targeted Triblock Copolymer Nanoparticle Delivers Thymidine Kinase-p53-Nitroreductase Triple Therapeutic Gene and Restores Anticancer Function against Hepatocellular Carcinoma in Vivo.

Prostate Cancer Phenotype Influences Bone Mineralization at Metastasis: A Study Using an In Vitro Prostate Cancer Metastasis Testbed.

Pathway-specific reporter genes to study stem cell biology.

Highly sensitive eight-channel light sensing system for biomedical applications.

Reconstructed Apoptotic Bodies as Targeted "Nano Decoys" to Treat Intracellular Bacterial Infections within Macrophages and Cancer Cells.