Klaas Nicolay

Improved subtraction by adiabatic FAIR perfusion imaging.

The quantitation of ADP diffusion gradients across the outer membrane of heart mitochondria in the presence of macromolecules.

Diffuse signal abnormalities in the spinal cord in multiple sclerosis: direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology.

Role of magnesium in the reduction of ischemic depolarization and lesion volume after experimental subarachnoid hemorrhage.

Reduction of cerebral injury in stroke-prone spontaneously hypertensive rats by amlodipine.

Neuroprotection by selective nitric oxide synthase inhibition at 24 hours after perinatal hypoxia-ischemia.

On the role of mi-cK and VDAC in mitochondrial function of heart muscle cells.

Pharmacological interventions in the newborn piglet in the first 24 h after hypoxia-ischemia. A hemodynamic and electrophysiological perspective.

Acute neuronal injury, excitotoxicity, and the endocannabinoid system.

In vivo excitotoxicity induced by ouabain, a Na+/K+-ATPase inhibitor.

Effects of allopurinol and deferoxamine on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia.

Biosynthesis of endocannabinoids and their modes of action in neurodegenerative diseases.

Effect of vascular crushing on FAIR perfusion kinetics, using a BIR-4 pulse in a magnetization prepared FLASH sequence.

Interferon-beta blocks infiltration of inflammatory cells and reduces infarct volume after ischemic stroke in the rat.

Interferon-beta prevents cytokine-induced neutrophil infiltration and attenuates blood-brain barrier disruption.

An MR-compatible device for the in situ assessment of isometric contractile performance of mouse hind-limb ankle flexors.

Magnetic resonance imaging in experimental models of brain disorders.

The mitochondrial outer membrane is not a major diffusion barrier for ADP in mouse heart skinned fibre bundles.

Comparison of FAIR perfusion kinetics with DSC-MRI and functional histology in a model of transient ischemia.

The use of high-resolution magnetic resonance imaging for monitoring interbody fusion and bioabsorbable cages: an ex vivo pilot study.

MR imaging of mouse leptomeningeal metastases.

A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets.

In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium-pilocarpine-induced status epilepticus in the rat.

Mitochondrial affinity for ADP is twofold lower in creatine kinase knock-out muscles. Possible role in rescuing cellular energy homeostasis.

Determination of mouse skeletal muscle architecture using three-dimensional diffusion tensor imaging.

The effect of B1 field inhomogeneity and the nonselective inversion profile on the kinetics of FAIR-based perfusion MRI.

MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle.

Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe.

Intramyocellular lipid content and molecular adaptations in response to a 1-week high-fat diet.

Monitoring of moisture redistribution in multicomponent food systems by use of magnetic resonance imaging.

Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging.

Increased resistance to fatigue in creatine kinase deficient muscle is not due to improved contractile economy.

Liposome-enhanced MRI of neointimal lesions in the ApoE-KO mouse.

Annexin A5-functionalized bimodal lipid-based contrast agents for the detection of apoptosis.

Regional variations in intramyocellular lipid concentration correlate with muscle fiber type distribution in rat tibialis anterior muscle.

Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy.

DTI-based assessment of ischemia-reperfusion in mouse skeletal muscle.

Annexin A5-conjugated quantum dots with a paramagnetic lipidic coating for the multimodal detection of apoptotic cells.

1H MR spectroscopy of the brain: absolute quantification of metabolites.

Quantitative MRI-pathology correlations of brain white matter lesions developing in a non-human primate model of multiple sclerosis.

Dynamic MRS and MRI of skeletal muscle function and biomechanics.

Comparison between prospective and retrospective triggering for mouse cardiac MRI.

Early in vivo assessment of angiostatic therapy efficacy by molecular MRI.

Role of ischemia and deformation in the onset of compression-induced deep tissue injury: MRI-based studies in a rat model.

Anginex-conjugated liposomes for targeting of angiogenic endothelial cells.

Skeletal muscle degeneration and regeneration after femoral artery ligation in mice: monitoring with diffusion MR imaging.

Intersubject differences in the effect of acidosis on phosphocreatine recovery kinetics in muscle after exercise are due to differences in proton efflux rates.

MRI contrast agents: current status and future perspectives.

Reproducibility of quantitative cerebral T2 relaxometry, diffusion tensor imaging, and 1H magnetic resonance spectroscopy at 3.0 Tesla.

Exercise training improves glycemic control in long-standing insulin-treated type 2 diabetic patients.

多模态成像的磁性和荧光纳米颗粒。

Magnetic resonance molecular imaging contrast agents and their application in atherosclerosis.

Molecular imaging of macrophages in atherosclerotic plaques using bimodal PEG-micelles.

Evaluation of manual and automatic segmentation of the mouse heart from CINE MR images.

Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: a multimodality investigation.

Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes.

Short- and long-term limbic abnormalities after experimental febrile seizures.

Diffusion tensor imaging of left ventricular remodeling in response to myocardial infarction in the mouse.

A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging.

Kinetics of avidin-induced clearance of biotinylated bimodal liposomes for improved MR molecular imaging.

Paramagnetic lipid-coated silica nanoparticles with a fluorescent quantum dot core: a new contrast agent platform for multimodality imaging.

Improved magnetic resonance molecular imaging of tumor angiogenesis by avidin-induced clearance of nonbound bimodal liposomes.

Molecular imaging of tumor angiogenesis using alphavbeta3-integrin targeted multimodal quantum dots.

Quantification of left ventricular volumes and ejection fraction in mice using PET, compared with MRI.

Well-defined, multifunctional nanostructures of a paramagnetic lipid and a lipopeptide for macrophage imaging.

Internalization of annexin A5-functionalized iron oxide particles by apoptotic Jurkat cells.

Three-compartment T1 relaxation model for intracellular paramagnetic contrast agents.

Cellular compartmentalization of internalized paramagnetic liposomes strongly influences both T1 and T2 relaxivity.

On the use of steady-state signal equations for 2D TrueFISP imaging.

Synergy between anti-CCL2 and docetaxel as determined by DW-MRI in a metastatic bone cancer model.

Nanoparticulate assemblies of amphiphiles and diagnostically active materials for multimodality imaging.

Magnitude and control of mitochondrial sensitivity to ADP.

Silencing of glycolysis in muscle: experimental observation and numerical analysis.

Chitosan-based systems for molecular imaging.

Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats.

Diffusion of water in skeletal muscle tissue is not influenced by compression in a rat model of deep tissue injury.

An MR-compatible bicycle ergometer for in-magnet whole-body human exercise testing.

Synergistic targeting of alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis.

Magnetic quantum dots for multimodal imaging.

Current applications of nanotechnology for magnetic resonance imaging of apoptosis.

MRI-determined carotid artery flow velocities and wall shear stress in a mouse model of vulnerable and stable atherosclerotic plaque.

Skeletal muscle metabolic recovery following submaximal exercise in chronic heart failure is limited more by O(2) delivery than O(2) utilization.

Paramagnetic and fluorescent liposomes for target-specific imaging and therapy of tumor angiogenesis.

Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents.

Quantum dots for multimodal molecular imaging of angiogenesis.

Quantitative (1)H MRI, (19)F MRI, and (19)F MRS of cell-internalized perfluorocarbon paramagnetic nanoparticles.

Reproducibility of diffusion tensor imaging in human forearm muscles at 3.0 T in a clinical setting.

Surface modification of PLGA nanospheres with Gd-DTPA and Gd-DOTA for high-relaxivity MRI contrast agents.

Annexin A5-functionalized bimodal nanoparticles for MRI and fluorescence imaging of atherosclerotic plaques.

Contrast enhancement by differently sized paramagnetic MRI contrast agents in mice with two phenotypes of atherosclerotic plaque.

Mouse myocardial first-pass perfusion MR imaging.

Dynamic changes in 1H-MR relaxometric properties of cell-internalized paramagnetic liposomes, as studied over a five-day period.

Three-dimensional T1 mapping of the mouse heart using variable flip angle steady-state MR imaging.

Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis.

Photochemical activation of endosomal escape of MRI-Gd-agents in tumor cells.

The binding of CNA35 contrast agents to collagen fibrils.

Anti-tumor activity of liposomal glucocorticoids: The relevance of liposome-mediated drug delivery, intratumoral localization and systemic activity.

Multi-parametric assessment of the anti-angiogenic effects of liposomal glucocorticoids.

Tumor targeting of MMP-2/9 activatable cell-penetrating imaging probes is caused by tumor-independent activation.

Similar mitochondrial activation kinetics in wild-type and creatine kinase-deficient fast-twitch muscle indicate significant Pi control of respiration.

差异影响的短期和长期高脂肪饮食喂养大鼠肝脂肪酸代谢。

Fasting-induced myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice is accompanied by impaired left ventricular function.

The effects of deformation, ischemia, and reperfusion on the development of muscle damage during prolonged loading.

Target-specific paramagnetic and superparamagnetic micelles for molecular MR imaging.

Regional contrast agent quantification in a mouse model of myocardial infarction using 3D cardiac T1 mapping.

Pioglitazone modulates vascular inflammation in atherosclerotic rabbits noninvasive assessment with FDG-PET-CT and dynamic contrast-enhanced MR imaging.

Myofibrillar distribution of succinate dehydrogenase activity and lipid stores differs in skeletal muscle tissue of paraplegic subjects.

Dual-targeting of α(v)β(3) and galectin-1 improves the specificity of paramagnetic/fluorescent liposomes to tumor endothelium in vivo.

In vivo characterization of a new abdominal aortic aneurysm mouse model with conventional and molecular magnetic resonance imaging.

Multitissue assessment of in vivo postprandial intracellular lipid partitioning in rats using localized (1) H-[(13) C] magnetic resonance spectroscopy.

Contrast-enhanced MRI of murine myocardial infarction - Part I.

Molecular MRI of Inflammation in Atherosclerosis.

Contrast-enhanced MRI of murine myocardial infarction - Part II.

Diffusion-tensor MRI reveals the complex muscle architecture of the human forearm.