Matthias Klugmann

Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation.

Development and optimization of adeno-associated virus vector transfer into the central nervous system.

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection.

Identification and distribution of aspartoacylase in the postnatal rat brain.

Homer proteins regulate sensitivity to cocaine.

AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats.

Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease.

Activity-dependent subcellular localization of NAC1.

Homer2 is necessary for EtOH-induced neuroplasticity.

Homer isoforms differentially regulate cocaine-induced neuroplasticity.

A novel role of circadian transcription factor DBP in hippocampal plasticity.

Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function.

Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain.

Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice.

The endocannabinoid system controls key epileptogenic circuits in the hippocampus.

Accumbens Homer2 overexpression facilitates alcohol-induced neuroplasticity in C57BL/6J mice.

NAC1 regulates the recruitment of the proteasome complex into dendritic spines.

Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice.

AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease.

Targeting Homer genes using adeno-associated viral vector: lessons learned from behavioural and neurochemical studies.

Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine.

Rapid, reproducible transduction of select forebrain regions by targeted recombinant virus injection into the neonatal mouse brain.

Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism.

Synaptic inhibition in the olfactory bulb accelerates odor discrimination in mice.

Semaphorin 6A improves functional recovery in conjunction with motor training after cerebral ischemia.

Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking.

CNS-targeted viral delivery of G-CSF in an animal model for ALS: improved efficacy and preservation of the neuromuscular unit.

AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity.

Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels.

Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.

AAV-Mediated Overexpression of the CB1 Receptor in the mPFC of Adult Rats Alters Cognitive Flexibility, Social Behavior, and Emotional Reactivity.

Nerve terminal nicotinic acetylcholine receptors initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca²⁺ channels and Ca²⁺ release from stores.

Optogenetic release of ACh induces rhythmic bursts of perisomatic IPSCs in hippocampus.