Jay Unruh

BAC modification through serial or simultaneous use of CRE/Lox technology.

Gamma-tubulin is required for bipolar spindle assembly and for proper kinetochore microtubule attachments during prometaphase I in Drosophila oocytes.

Fluorescence fluctuation spectroscopy and imaging methods for examination of dynamic protein interactions in yeast.

Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes.

Motility and segregation of Hsp104-associated protein aggregates in budding yeast.

The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis.

Critical role of amyloid-like oligomers of Drosophila Orb2 in the persistence of memory.

Flippase-mediated phospholipid asymmetry promotes fast Cdc42 recycling in dynamic maintenance of cell polarity.

The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration.

Acetylation of the SUN protein Mps3 by Eco1 regulates its function in nuclear organization.

Actin depolymerization drives actomyosin ring contraction during budding yeast cytokinesis.

Cohesin proteins promote ribosomal RNA production and protein translation in yeast and human cells.

Cell-cycle-coupled structural oscillation of centromeric nucleosomes in yeast.

Non-uniform membrane diffusion enables steady-state cell polarization via vesicular trafficking.

Quality control: putting protein aggregates in a bind.

Sequential actin-based pushing forces drive meiosis I chromosome migration and symmetry breaking in oocytes.

Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains.

Independence of symmetry breaking on Bem1-mediated autocatalytic activation of Cdc42.

Cohesion promotes nucleolar structure and function.

The SUN protein Mps3 controls Ndc1 distribution and function on the nuclear membrane.

Corolla is a novel protein that contributes to the architecture of the synaptonemal complex of Drosophila.

The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex.

Organelle-based aggregation and retention of damaged proteins in asymmetrically dividing cells.

Imaging methodologies for systems biology.

Analysis of dynamic changes in retinoid-induced transcription and epigenetic profiles of murine Hox clusters in ES cells.

Structured illumination with particle averaging reveals novel roles for yeast centrosome components during duplication.

Vilya, a component of the recombination nodule, is required for meiotic double-strand break formation in Drosophila.

Sec66-Dependent Regulation of Yeast Spindle-Pole Body Duplication Through Pom152.

Mitotic Transcriptional Activation: Clearance of Actively Engaged Pol II via Transcriptional Elongation Control in Mitosis.

Amyloidogenic Oligomerization Transforms Drosophila Orb2 from a Translation Repressor to an Activator.

Karyotyping human and mouse cells using probes from single-sorted chromosomes and open source software.

Intracellular chloride concentration of the mouse vomeronasal neuron.

Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation.

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

A Putative Biochemical Engram of Long-Term Memory.

Analysis of membrane proteins localizing to the inner nuclear envelope in living cells.

Dynamic regulation of Nanog and stem cell-signaling pathways by Hoxa1 during early neuro-ectodermal differentiation of ES cells.

Molecular model of fission yeast centrosome assembly determined by superresolution imaging.

Ribosomal DNA copy number loss and sequence variation in cancer.

Superresolution expansion microscopy reveals the three-dimensional organization of the synaptonemal complex.

HOXA1 and TALE proteins display cross-regulatory interactions and form a combinatorial binding code on HOXA1 targets.

Structural plasticity of the living kinetochore.

Integrative structure and functional anatomy of a nuclear pore complex.

The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion.

Quantifying Nucleation In Vivo Reveals the Physical Basis of Prion-like Phase Behavior.

Combined expansion microscopy with structured illumination microscopy for analyzing protein complexes.

Functional Analysis of the Yeast LINC Complex Using Fluctuation Spectroscopy and Super-Resolution Imaging.

N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.

Distribution of Proteins at the Inner Nuclear Membrane Is Regulated by the Asi1 E3 Ligase in .

Imaging-based assays for investigating functions of the RNA polymerase II elongation factor Elongin and the Elongin ubiquitin ligase.

Yeast centrosome components form a noncanonical LINC complex at the nuclear envelope insertion site.

Dopamine receptor antagonists as potential therapeutic agents for ADPKD.

The stoichiometry of the outer kinetochore is modulated by microtubule-proximal regulatory factors.

Superresolution microscopy reveals linkages between ribosomal DNA on heterologous chromosomes.

PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation.

Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo.

chromosome and autosomal recombination are differentially sensitive to disruptions in SC maintenance.

β-Catenin and Associated Proteins Regulate Lineage Differentiation in Ground State Mouse Embryonic Stem Cells.

Orderly assembly underpinning built-in asymmetry in the yeast centrosome duplication cycle requires cyclin-dependent kinase.

Driving integrative structural modeling with serial capture affinity purification.

Super-resolution Microscopy-based Bimolecular Fluorescence Complementation to Study Protein Complex Assembly and Co-localization.

A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription.

Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast.

Proteome plasticity in response to persistent environmental change.

Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling.

Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche.