Reinis Vilskersts

Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis.

Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction.

Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart.

Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.

Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.

Effects of long-term mildronate treatment on cardiac and liver functions in rats.

The anti-inflammatory and antinociceptive effects of NF-kappaB inhibitory guanidine derivative ME10092.

Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.

The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.

Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus.

Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.

Elevated vascular γ-butyrobetaine levels attenuate the development of high glucose-induced endothelial dysfunction.

The heart is better protected against myocardial infarction in the fed state compared to the fasted state.

Magnesium nitrate attenuates blood pressure rise in SHR rats.

Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size.

Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity.

Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria.

Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria.

Acute and long-term administration of palmitoylcarnitine induces muscle-specific insulin resistance in mice.

Delivery Systems for Birch-bark Triterpenoids and their Derivatives in Anticancer Research.

Mitochondrial Function in the Kidney and Heart, but Not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia.

Sulfonyl Group Dance: A Tool for the Synthesis of 6-Azido-2-sulfonylpurine Derivatives.

4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action.

Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia.

Rats with congenital hydronephrosis show increased susceptibility to renal ischemia-reperfusion injury.

Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure.

Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage.

Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19.