Laboratory of Pharmaceutical Pharmacology
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Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis.
Vascular pharmacology Sep, 2015 | Pubmed ID: 25989106
Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction.
Journal of cardiovascular pharmacology Dec, 2006 | Pubmed ID: 17204911
Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart.
Life sciences Oct, 2008 | Pubmed ID: 18801379
Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.
Cardiovascular drugs and therapy Aug, 2009 | Pubmed ID: 19536647
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.
British journal of pharmacology Aug, 2009 | Pubmed ID: 19594753
Effects of long-term mildronate treatment on cardiac and liver functions in rats.
Basic & clinical pharmacology & toxicology Dec, 2009 | Pubmed ID: 19663820
The anti-inflammatory and antinociceptive effects of NF-kappaB inhibitory guanidine derivative ME10092.
International immunopharmacology Apr, 2010 | Pubmed ID: 20074673
Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.
Pharmacological reports : PR , 2011 | Pubmed ID: 21857086
The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.
Journal of cardiovascular pharmacology and therapeutics Jun, 2012 | Pubmed ID: 21903968
Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus.
The journal of physiological sciences : JPS Nov, 2012 | Pubmed ID: 22893478
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Bioorganic & medicinal chemistry May, 2013 | Pubmed ID: 23582449
Elevated vascular γ-butyrobetaine levels attenuate the development of high glucose-induced endothelial dysfunction.
Clinical and experimental pharmacology & physiology Aug, 2013 | Pubmed ID: 23710938
The heart is better protected against myocardial infarction in the fed state compared to the fasted state.
Metabolism: clinical and experimental Jan, 2014 | Pubmed ID: 24140100
Magnesium nitrate attenuates blood pressure rise in SHR rats.
Magnesium research Jan-Mar, 2014 | Pubmed ID: 24827813
Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size.
Pharmacological research Jul, 2014 | Pubmed ID: 24836867
Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity.
Pharmacological research 11, 2016 | Pubmed ID: 26850121
Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria.
The Biochemical journal 05, 2016 | Pubmed ID: 26936967
Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria.
Toxicology letters Feb, 2017 | Pubmed ID: 28049038
Acute and long-term administration of palmitoylcarnitine induces muscle-specific insulin resistance in mice.
BioFactors (Oxford, England) Sep, 2017 | Pubmed ID: 28759135
Delivery Systems for Birch-bark Triterpenoids and their Derivatives in Anticancer Research.
Current medicinal chemistry , 2020 | Pubmed ID: 29848269
Mitochondrial Function in the Kidney and Heart, but Not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia.
Shock (Augusta, Ga.) 12, 2019 | Pubmed ID: 30640252
Sulfonyl Group Dance: A Tool for the Synthesis of 6-Azido-2-sulfonylpurine Derivatives.
The Journal of organic chemistry 04, 2020 | Pubmed ID: 32150410
4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action.
Oxidative medicine and cellular longevity , 2020 | Pubmed ID: 32308799
Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia.
Journal of cellular and molecular medicine 10, 2020 | Pubmed ID: 32896106
Rats with congenital hydronephrosis show increased susceptibility to renal ischemia-reperfusion injury.
Physiological reports 11, 2020 | Pubmed ID: 33207081
Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure.
Frontiers in cell and developmental biology , 2020 | Pubmed ID: 33520996
Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage.
Free radical biology & medicine 12, 2021 | Pubmed ID: 34728372
Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19.
International journal of molecular sciences Dec, 2021 | Pubmed ID: 35008470
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