Nicholas O. Fischer

Heightened sense for sensing: recent advances in pathogen immunoassay sensing platforms.

Aptasensors for biosecurity applications.

Protein detection via direct enzymatic amplification of short DNA aptamers.

Single microbead SELEX for efficient ssDNA aptamer generation against botulinum neurotoxin.

Massively parallel interrogation of aptamer sequence, structure and function.

Sensitive and selective viral DNA detection assay via microbead-based rolling circle amplification.

Biofunctional subwavelength optical waveguides for biodetection.

Immobilization of His-tagged proteins on nickel-chelating nanolipoprotein particles.

Hydrogen production by a hyperthermophilic membrane-bound hydrogenase in water-soluble nanolipoprotein particles.

Conjugation to nickel-chelating nanolipoprotein particles increases the potency and efficacy of subunit vaccines to prevent West Nile encephalitis.

Kinetic analysis of his-tagged protein binding to nickel-chelating nanolipoprotein particles.

Isolation, characterization, and stability of discretely-sized nanolipoprotein particles assembled with apolipophorin-III.

Identification and optimization of DNA aptamer binding regions using DNA microarrays.

Enhanced cellulose degradation using cellulase-nanosphere complexes.

Colocalized delivery of adjuvant and antigen using nanolipoprotein particles enhances the immune response to recombinant antigens.

The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge.

Quantifying interactions of a membrane protein embedded in a lipid nanodisc using fluorescence correlation spectroscopy.

Evaluation of nanolipoprotein particles (NLPs) as an in vivo delivery platform.

Enhancing the efficacy of innate immune agonists: could nanolipoprotein particles hold the key?

Nanoparticles and antigen delivery: understanding the benefits and drawbacks of different delivery platforms.

Fluorescence correlation spectroscopy at micromolar concentrations without optical nanoconfinement.

Lipid Cross-Linking of Nanolipoprotein Particles Substantially Enhances Serum Stability and Cellular Uptake.

Enhancement of antigen-specific CD4 and CD8 T cell responses using a self-assembled biologic nanolipoprotein particle vaccine.

Cell-free production of a functional oligomeric form of a major outer-membrane protein (MOMP) for vaccine development.

Small-angle X-ray and neutron scattering demonstrates that cell-free expression produces properly formed disc-shaped nanolipoprotein particles.

Lipid composition dictates serum stability of reconstituted high-density lipoproteins: implications for in vivo applications.

Evaluation of in vitro neuronal platforms as surrogates for in vivo whole brain systems.

Extent of MHC Clustering Regulates Selectivity and Effectiveness of T Cell Responses.

Tissue-specific extracellular matrix accelerates the formation of neural networks and communities in a neuron-glia co-culture on a multi-electrode array.

Optimizing cell encapsulation condition in ECM-Collagen I hydrogels to support 3D neuronal cultures.

A Reconfigurable In Vitro Model for Studying the Blood-Brain Barrier.

A flexible 3-dimensional microelectrode array for in vitro brain models.

Cationic HDL mimetics enhance in vivo delivery of self-replicating mRNA.

HIV influences microtubule associated protein-2: potential marker of HIV-associated neurocognitive disorders.

Modeling the temporal network dynamics of neuronal cultures.

Functional and transcriptional characterization of complex neuronal co-cultures.

Characterization of Spore Proteins Using a Nanoscaffold Vaccine Platform.

Intranasal Nanoparticle Vaccination Elicits a Persistent, Polyfunctional CD4 T Cell Response in the Murine Lung Specific for a Highly Conserved Influenza Virus Antigen That Is Sufficient To Mediate Protection from Influenza Virus Challenge.

Induction of Protection in Mice against a Respiratory Challenge by a Vaccine Formulated with the Major Outer Membrane Protein in Nanolipoprotein Particles.

Probing function in 3D neuronal cultures: A survey of 3D multielectrode array advances.

A Survey of Preclinical Studies Evaluating Nanoparticle-Based Vaccines Against Non-Viral Sexually Transmitted Infections.