Myriam Gorospe

Functional role of p21 during the cellular response to stress.

von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays.

Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity.

Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function.

An in vitro model of caloric restriction.

RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation.

HuR in the mammalian genotoxic response: post-transcriptional multitasking.

Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells.

Identification of a target RNA motif for RNA-binding protein HuR.

Global mRNA stabilization preferentially linked to translational repression during the endoplasmic reticulum stress response.

Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs.

AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR.

Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuR.

Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity.

Enhanced proliferation of cultured human vascular smooth muscle cells linked to increased function of RNA-binding protein HuR.

Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.

Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha.

En masse analysis of nascent translation using microarrays.

Clean Western blot signals from immunoprecipitated samples.

Translational repression by RNA-binding protein TIAR.

En masse nascent transcription analysis to elucidate regulatory transcription factors.

Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR.

Posttranscriptional derepression of GADD45alpha by genotoxic stress.

Egad, more forms of gene regulation: the gadd45a story.

Differential stability of thymidylate synthase 3'-untranslated region polymorphic variants regulated by AUF1.

Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets.

HuR: post-transcriptional paths to malignancy.

Phosphorylation of HuR by Chk2 regulates SIRT1 expression.

Posttranscriptional orchestration of an anti-apoptotic program by HuR.

Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAs.

Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR.

Kinetic analysis of butyrate transport in human colon adenocarcinoma cells reveals two different carrier-mediated mechanisms.

Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells.

Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1.

RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha.

AGEMAP: a gene expression database for aging in mice.

Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence.

AsSIRTing the DNA damage response.

GU-rich RNA: expanding CUGBP1 function, broadening mRNA turnover.

Posttranscriptional regulation of IL-13 in T cells: role of the RNA-binding protein HuR.

p16(INK4a) translation suppressed by miR-24.

MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90.

JunD represses transcription and translation of the tight junction protein zona occludens-1 modulating intestinal epithelial barrier function.

Nuclear HuR accumulation through phosphorylation by Cdk1.

Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.

Protecting the stress response, guarding the MKP-1 mRNA.

Phosphorylated HuR shuttles in cycles.

Modification at HuR(S242) alters HuR localization and proliferative influence.

Identification of a signature motif in target mRNAs of RNA-binding protein AUF1.

miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels.

The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA.

Analysis of nitric oxide-stabilized mRNAs in human fibroblasts reveals HuR-dependent heme oxygenase 1 upregulation.

Ribosomal protein mRNAs are primary targets of regulation in RNase-L-induced senescence.

Novel roles of hakai in cell proliferation and oncogenesis.

HuR recruits let-7/RISC to repress c-Myc expression.

RNA-binding proteins implicated in the hypoxic response.

Ribonucleoprotein dynamics connects mRNA networks with drug mechanisms.

Factors interacting with HIF-1alpha mRNA: novel therapeutic targets.

HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity.

Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation.

NF90 selectively represses the translation of target mRNAs bearing an AU-rich signature motif.

Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs.

The 'RNA-binding ome': future implications for chemotherapeutic efficacy.

Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence.

Minireview: posttranscriptional regulation of the insulin and insulin-like growth factor systems.

HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.

Post-transcriptional regulation of androgen receptor mRNA by an ErbB3 binding protein 1 in prostate cancer.

miR-519 suppresses tumor growth by reducing HuR levels.

hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies.

HuR uses AUF1 as a cofactor to promote p16INK4 mRNA decay.

microRNA expression patterns reveal differential expression of target genes with age.

The human glucocorticoid receptor as an RNA-binding protein: global analysis of glucocorticoid receptor-associated transcripts and identification of a target RNA motif.

pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs.

ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes.

Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium.

Different modes of interaction by TIAR and HuR with target RNA and DNA.

Paradoxical microRNAs: individual gene repressors, global translation enhancers.

Role of RNA binding protein HuR in ductal carcinoma in situ of the breast.

Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyamines.

Post-Transcriptional Control of the Hypoxic Response by RNA-Binding Proteins and MicroRNAs.

Altered glycobiology of stem cells linked to age-related osteoarthritis.

UneCLIPsing HuR nuclear function.

Impact of pyrrolidine dithiocarbamate and interleukin-6 on mammalian target of rapamycin complex 1 regulation and global protein translation.

miR-503 represses CUG-binding protein 1 translation by recruiting CUGBP1 mRNA to processing bodies.

Array-based nuclear run-on analysis.

The oncogenic RNA-binding protein Musashi1 is regulated by HuR via mRNA translation and stability in glioblastoma cells.

SRT1720 improves survival and healthspan of obese mice.

RNA-binding protein HuD controls insulin translation.

The tRNA methyltransferase NSun2 stabilizes p16INK⁴ mRNA by methylating the 3'-untranslated region of p16.

Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation.

Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation.

The RNA-binding protein human antigen R controls global changes in gene expression during Schwann cell development.

RNA-binding protein nucleolin in disease.

LincRNA-p21 suppresses target mRNA translation.

NF90 coordinately represses the senescence-associated secretory phenotype.

Competitive binding of CUGBP1 and HuR to occludin mRNA controls its translation and modulates epithelial barrier function.

Posttranscriptional gene regulation by long noncoding RNA.

Modulation of cancer traits by tumor suppressor microRNAs.

Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB.

Distinct binding properties of TIAR RRMs and linker region.

MicroRNA 33 regulates glucose metabolism.

Senescence-associated lncRNAs: senescence-associated long noncoding RNAs.

Loss of CARM1 is linked to reduced HuR function in replicative senescence.

miR-29b represses intestinal mucosal growth by inhibiting translation of cyclin-dependent kinase 2.

Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation.

Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction.

The RNA-binding protein HuD regulates autophagosome formation in pancreatic β cells by promoting autophagy-related gene 5 expression.

Conditional knockout of the RNA-binding protein HuR in CD4⁺ T cells reveals a gene dosage effect on cytokine production.

Inhibition of Smurf2 translation by miR-322/503 modulates TGF-β/Smad2 signaling and intestinal epithelial homeostasis.

dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: a dual-institutional follow-up with the RTOG 9704 trial.

RNA binding protein HuR regulates the expression of ABCA1.

RNA-binding protein AUF1 promotes myogenesis by regulating MEF2C expression levels.

Functional interactions among microRNAs and long noncoding RNAs.

Destabilization of nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fibre formation.

Methylation by NSun2 represses the levels and function of microRNA 125b.

7SL RNA represses p53 translation by competing with HuR.

Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection.

RNA-binding protein HuR promotes growth of small intestinal mucosa by activating the Wnt signaling pathway.

Modulation by miR-29b of intestinal epithelium homoeostasis through the repression of menin translation.

Novel RNA-binding protein P311 binds eukaryotic translation initiation factor 3 subunit b (eIF3b) to promote translation of transforming growth factor β1-3 (TGF-β1-3).

Long noncoding RNA turnover.

JunD enhances miR-29b levels transcriptionally and posttranscriptionally to inhibit proliferation of intestinal epithelial cells.

Competition between RNA-binding proteins CELF1 and HuR modulates MYC translation and intestinal epithelium renewal.

RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma.

Long noncoding RNAs in diseases of aging.

miR-431 promotes differentiation and regeneration of old skeletal muscle by targeting Smad4.

Transgenic Expression of miR-222 Disrupts Intestinal Epithelial Regeneration by Targeting Multiple Genes Including Frizzled-7.

AUF1 promotes let-7b loading on Argonaute 2.

B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo.

Noncoding RNA control of cellular senescence.

NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation.

Posttranscriptional Regulation of the Inflammatory Marker C-Reactive Protein by the RNA-Binding Protein HuR and MicroRNA 637.

Circular RNAs in monkey muscle: age-dependent changes.

Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity.

CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs.

Long noncoding RNA SPRY4-IT1 regulates intestinal epithelial barrier function by modulating the expression levels of tight junction proteins.

NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation.

Cross-Linking Immunoprecipitation and qPCR (CLIP-qPCR) Analysis to Map Interactions Between Long Noncoding RNAs and RNA-Binding Proteins.

LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR.

Identification of mRNA-Interacting Factors by MS2-TRAP (MS2-Tagged RNA Affinity Purification).

Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence.

RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence.

HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP.

Mammalian ataxin-2 modulates translation control at the pre-initiation complex via PI3K/mTOR and is induced by starvation.

RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals.

RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cystic fibrosis lung epithelium by upregulating CTGF.

Posttranslational control of HuR function.

Identification of neural stem cell differentiation repressor complex Pnky-PTBP1.

Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation.

The long and the short of TRF2 in neurogenesis.

HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy.

Emerging roles and context of circular RNAs.

Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA.

RT-qPCR Detection of Senescence-Associated Circular RNAs.

UNRelenting Translation UNRestrains Melanoma Migration.

Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1.

Bioinformatic tools for analysis of CLIP ribonucleoprotein data.

HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation.

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.

Mitochondrial noncoding RNA transport.

RNA in extracellular vesicles.

TIA-1 RRM23 binding and recognition of target oligonucleotides.

NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation.

High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs.

Overexpression of the Cytokine BAFF and Autoimmunity Risk.

Affinity Pulldown of Biotinylated RNA for Detection of Protein-RNA Complexes.

Polysome Fractionation to Analyze mRNA Distribution Profiles.

The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells.

Senescence-Associated MicroRNAs.

Identification of senescent cell surface targetable protein DPP4.

Regulation of HuR structure and function by dihydrotanshinone-I.

Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195.

STIM1, but not STIM2, Is the Calcium Sensor Critical for Sweat Secretion.

Analysis of Circular RNAs Using the Web Tool CircInteractome.

Noncoding RNAs in Alzheimer's disease.

Cytoplasmic functions of long noncoding RNAs.

A RAS-CaMKKβ-AMPKα2 pathway promotes senescence by licensing post-translational activation of C/EBPβ through a novel 3'UTR mechanism.

Detection and Analysis of Circular RNAs by RT-PCR.

HuR regulates telomerase activity through TERC methylation.

SCAMP4 enhances the senescent cell secretome.

Author Correction: HuR regulates telomerase activity through TERC methylation.

AKTions by Cytoplasmic lncRNA CASC9 Promote Hepatocellular Carcinoma Survival.

GRSF1 suppresses cell senescence.

Identifying intronic circRNAs: progress and challenges.

Multi-leveled suppression of p53 function by HuR IncRNPs.

The coding potential of circRNAs.

Cooperative translational control of polymorphic BAFF by NF90 and miR-15a.

Intracellular RNA-tracking methods.

RPAD (RNase R treatment, polyadenylation, and poly(A)+ RNA depletion) method to isolate highly pure circular RNA.

Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program.

NF90 regulation of immune factor expression in response to malaria antigens.

Loss of miR-451a enhances SPARC production during myogenesis.

Long noncoding RNAs in intestinal epithelium homeostasis.

RNA-Binding Protein HuR Regulates Paneth Cell Function by Altering Membrane Localization of TLR2 via Post-transcriptional Control of CNPY3.

mRNA methylation in cell senescence.

Correction: Polysome Fractionation to Analyze mRNA Distribution Profiles.

Transcriptome signature of cellular senescence.

HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling.

Skewed macrophage polarization in aging skeletal muscle.

Methods for analysis of circular RNAs.

'RNA circles of influence' in Kaposi sarcoma.

Transcriptome signature of cellular senescence.

Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria.

SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model.

HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A.

Long Noncoding RNA H19 Impairs the Intestinal Barrier by Suppressing Autophagy and Lowering Paneth and Goblet Cell Function.

circSamd4 represses myogenic transcriptional activity of PUR proteins.

A Circular RNA from the Locus Controls Cell Cycle Progression by Suppressing p53 Levels.

Survey of senescent cell markers with age in human tissues.

RNA-Binding Protein HuR Promotes Th17 Cell Differentiation and Can Be Targeted to Reduce Autoimmune Neuroinflammation.

Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging.

Regulation of senescence traits by MAPKs.

Hepatic HuR modulates lipid homeostasis in response to high-fat diet.

Circular RNAs in Blood Malignancies.

Complex genetic signatures in immune cells underlie autoimmunity and inform therapy.

Author Correction: Complex genetic signatures in immune cells underlie autoimmunity and inform therapy.

Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS.

Translational Control during Cellular Senescence.

A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells.

Practical guide for circular RNA analysis: Steps, tips, and resources.

Evolutionarily Selected Overexpression of the Cytokine BAFF Enhances Mucosal Immune Response Against .

Publisher Correction: Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS.

Interaction of OIP5-AS1 with MEF2C mRNA promotes myogenic gene expression.

NQO1 protects obese mice through improvements in glucose and lipid metabolism.

Mitochondrial RNA in Alzheimer's Disease Circulating Extracellular Vesicles.

Characterizing and circumventing sequence restrictions for synthesis of circular RNA in vitro.

AUF1 ligand circPCNX reduces cell proliferation by competing with p21 mRNA to increase p21 production.

Ribosome profiling analysis of human skeletal muscle identifies reduced translation of mitochondrial proteins with age.

HuB and HuD repress telomerase activity by dissociating HuR from TERC.

Ribonucleoprotein Immunoprecipitation (RIP) Analysis.

hnRNPK-regulated LINC00263 promotes malignant phenotypes through miR-147a/CAPN2.

Skeletal muscle transcriptome in healthy aging.

GRSF1 deficiency in skeletal muscle reduces endurance in aged mice.

Acid ceramidase promotes senescent cell survival.

Circular RNA CircHIPK3 Promotes Homeostasis of the Intestinal Epithelium by Reducing MicroRNA 29b Function.

Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis.

SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells.

Identification of circRNA-Interacting Proteins by Affinity Pulldown.

Systematic Identification of circRNAs in Alzheimer's Disease.

A brain proteomic signature of incipient Alzheimer's disease in young ε4 carriers identifies novel drug targets.

Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation.

The versatile role of HuR in Glioblastoma and its potential as a therapeutic target for a multi-pronged attack.

Systematic identification of NF90 target RNAs by iCLIP analysis.

Alternative polyadenylation utilization results in ribosome assembly and mRNA translation deficiencies in a model for muscle aging.