George Daley

Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells.

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.

Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems.

Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy.

HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.

Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336.

Prospects for stem cell therapeutics: myths and medicines.

Novel retroviral vectors to facilitate expression screens in mammalian cells.

Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

Dodging the magic bullet: understanding imatinib resistance.

Gleevec resistance: lessons for target-directed drug development.

A role for thrombopoietin in hemangioblast development.

Towards combination target-directed chemotherapy for chronic myeloid leukemia: role of farnesyl transferase inhibitors.

From embryos to embryoid bodies: generating blood from embryonic stem cells.

ES cells prove egg-straordinary.

Cloning and stem cells--handicapping the political and scientific debates.

Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5.

cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes.

Hematopoiesis from embryonic stem cells: lessons from and for ontogeny.

A screen to identify drug resistant variants to target-directed anti-cancer agents.

Realistic prospects for stem cell therapeutics.

Genetic complementation of cytokine signaling identifies central role of kinases in hematopoietic cell proliferation.

Derivation of embryonic germ cells and male gametes from embryonic stem cells.

Mechanisms and implications of imatinib resistance mutations in BCR-ABL.

Development of hematopoietic repopulating cells from embryonic stem cells.

小鼠胚胎干细胞自我更新与分化信号转导多元蛋白质组学分析。

Taking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system.

A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth.

Origins of mammalian hematopoiesis: in vivo paradigms and in vitro models.

Nuclear transplantation, embryonic stem cells and the potential for cell therapy.

Alchemy in the liver: fact or fusion?

Missed opportunities in embryonic stem-cell research.

LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells.

Bayesian analysis of signaling networks governing embryonic stem cell fate decisions.

Inducible transgene expression in mouse stem cells.

Chronic myeloid leukemia: proving ground for cancer stem cells.

In vitro gametogenesis from embryonic stem cells.

Altered nuclear transfer in stem-cell research - a flawed proposal.

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation.

Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation.

High-efficiency RNA interference in human embryonic stem cells.

Stem cell research: science, ethics and policy.

Customized human embryonic stem cells.

Patterning definitive hematopoietic stem cells from embryonic stem cells.

Therapeutic potential of embryonic stem cells.

Scientific and clinical opportunities for modeling blood disorders with embryonic stem cells.

Pilot study of lonafarnib, a farnesyl transferase inhibitor, in patients with chronic myeloid leukemia in the chronic or accelerated phase that is resistant or refractory to imatinib therapy.

Novel role for PDEF in epithelial cell migration and invasion.

Embryonic stem cell-derived hematopoietic stem cells.

Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor.

Anticipating clinical resistance to target-directed agents : the BCR-ABL paradigm.

Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance.

Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.

Male germ cells.

Transgene expression and RNA interference in embryonic stem cells.

Histocompatible embryonic stem cells by parthenogenesis.

Ethics. The ISSCR guidelines for human embryonic stem cell research.

The cdx-hox pathway in hematopoietic stem cell formation from embryonic stem cells.

Differentiation potential of histocompatible parthenogenetic embryonic stem cells.

The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.

Gametes from embryonic stem cells: a cup half empty or half full?

In vitro generation of germ cells from murine embryonic stem cells.

Towards hematopoietic reconstitution from embryonic stem cells: a sanguine future.

Farnesyl transferase inhibitor resistance probed by target mutagenesis.

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.

Human embryonic stem cells flock together.

Phase 1 study of lonafarnib (SCH 66336) and imatinib mesylate in patients with chronic myeloid leukemia who have failed prior single-agent therapy with imatinib.

Hemogenic endothelial progenitor cells isolated from human umbilical cord blood.

Debugging cellular reprogramming.

Current prospects for the generation of patient-specific pluripotent cells from adult tissues.

Towards the generation of patient-specific pluripotent stem cells for combined gene and cell therapy of hematologic disorders.

Reprogramming of human somatic cells to pluripotency with defined factors.

Human embryonic stem cell derivation from poor-quality embryos.

Enhanced plating efficiency of trypsin-adapted human embryonic stem cells is reversible and independent of trisomy 12/17.

Modulation of murine embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes.

Selective blockade of microRNA processing by Lin28.

Prospects for stem cell-based therapy.

Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome.

Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera.

Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer.

BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway.

Derivation and maintenance of human embryonic stem cells from poor-quality in vitro fertilization embryos.

Cdx gene deficiency compromises embryonic hematopoiesis in the mouse.

Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos.

Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.

Generation of human-induced pluripotent stem cells.

Molecular basis of pluripotency.

From fibroblasts to iPS cells: induced pluripotency by defined factors.

Disease-specific induced pluripotent stem cells.

Isolation of hematopoietic stem cells from mouse embryonic stem cells.

Activation of tyrosine kinases by mutation of the gatekeeper threonine.

Mesodermal patterning activity of SCL.

New ISSCR guidelines underscore major principles for responsible translational stem cell research.

Efficient gene knockdowns in human embryonic stem cells using lentiviral-based RNAi.

Human iPS cell derivation/reprogramming.

ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines.

Broader implications of defining standards for the pluripotency of iPSCs.

Generation of induced pluripotent stem cells from human blood.

Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.

Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells.

Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming.

Upping the ante: recent advances in direct reprogramming.

Functional evidence that the self-renewal gene NANOG regulates human tumor development.

Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells.

Biomechanical forces promote embryonic haematopoiesis.

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.

Lin28 promotes transformation and is associated with advanced human malignancies.

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment.

Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells.

Balancing work and life: a conversation with George Daley. Interviewed by Majlinda Lako and Susan Daher.

Cross-regulation of the Nanog and Cdx2 promoters.

9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.

A role for Lin28 in primordial germ-cell development and germ-cell malignancy.

microRNA expression during trophectoderm specification.

Disease models from pluripotent stem cells.

Hematopoietic development from human induced pluripotent stem cells.

Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells.

Generation of functional human hepatic endoderm from human induced pluripotent stem cells.

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts.

Autologous blood cell therapies from pluripotent stem cells.

A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells.

Application of induced pluripotent stem cells to hematologic disease.

AP24163 inhibits the gatekeeper mutant of BCR-ABL and suppresses in vitro resistance.

Stem cells: roadmap to the clinic.

Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.

Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage.

Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients.

Lin28: A microRNA regulator with a macro role.

AID for reprogramming.

Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity.

Interaction of retinoic acid and scl controls primitive blood development.

Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells.

Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis.

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies.

Straight talk with...George Daley. Interview by Elie Dolgin.

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.

Reprogramming of T cells from human peripheral blood.

Molecular basis of the first cell fate determination in mouse embryogenesis.

All-trans retinoic acid directs urothelial specification of murine embryonic stem cells via GATA4/6 signaling mechanisms.

Comprehensive methylome map of lineage commitment from haematopoietic progenitors.

Clump passaging and expansion of human embryonic and induced pluripotent stem cells on mouse embryonic fibroblast feeder cells.

Dynamic instability of genomic methylation patterns in pluripotent stem cells.

Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).

Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.

Another horse in the meta-stable state of pluripotency.

MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states.

Induced pluripotent stem cells: a novel frontier in the study of human primary immunodeficiencies.

Cellular therapy for fanconi anemia: the past, present, and future.

Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.

Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.

Somatic coding mutations in human induced pluripotent stem cells.

Investigating monogenic and complex diseases with pluripotent stem cells.

Interactions between Cdx genes and retinoic acid modulate early cardiogenesis.

Induced pluripotent stem cells for neural tissue engineering.

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.

Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice.

The nomenclature system should be sustainable, but also practical.

microRNAs become macro players in somatic cell reprogramming.

Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients.

Induced pluripotent stem cells for modelling human diseases.

From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond.

Telomere dynamics in dyskeratosis congenita: the long and the short of iPS.

Genomic approaches to deconstruct pluripotency.

Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.

Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity.

The Lin28/let-7 axis regulates glucose metabolism.

Stem cells: Triple genomes go far.

Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration.

Induced pluripotent stem cells--opportunities for disease modelling and drug discovery.

Cell cycle adaptations of embryonic stem cells.

Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells.

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.

Live-cell immunofluorescence staining of human pluripotent stem cells.

Polycomb repressive complex 2 regulates normal development of the mouse heart.

The promise of induced pluripotent stem cells in research and therapy.

Derivation of human embryonic stem cells with NEMO deficiency.

Overcoming Reprogramming Resistance of Fanconi Anemia Cells.

Chromatin-modifying enzymes as modulators of reprogramming.

Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway.

Reprogramming cellular identity for regenerative medicine.

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.

Accessing naïve human pluripotency.

Pluripotent stem cells in research and treatment of hemoglobinopathies.

Excision of a viral reprogramming cassette by delivery of synthetic Cre mRNA.

Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells.

Stem cells assessed.

Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient.

The promise and perils of stem cell therapeutics.

New lessons learned from disease modeling with induced pluripotent stem cells.

Caudal genes in blood development and leukemia.

Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates.

Therapeutic potential of human induced pluripotent stem cells in experimental stroke.

Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells.

Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions.

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells.

Influence of threonine metabolism on S-adenosylmethionine and histone methylation.

Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal.

The transcriptional landscape of hematopoietic stem cell ontogeny.

Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival.

Cellular alchemy and the golden age of reprogramming.

Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition.

A blueprint for engineering cell fate: current technologies to reprogram cell identity.

Reprogrammed cells for disease modeling and regenerative medicine.

Lin28a Regulates Germ Cell Pool Size and Fertility.

Induced pluripotent stem cells with a mitochondrial DNA deletion.

The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity.

Lin28: primal regulator of growth and metabolism in stem cells.

Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction.

Deciphering the rules of ceRNA networks.

Regulation of stem cell therapies under attack in Europe: for whom the bell tolls.

Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism.

Origins and implications of pluripotent stem cell variability and heterogeneity.

Stem cell metabolism in tissue development and aging.

Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells.

Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

A new route to human embryonic stem cells.

Optimization of scarless human stem cell genome editing.

A chemical logic for reprogramming to pluripotency.

Stem cells: Reprogramming in situ.

Hematopoietic defects and iPSC disease modeling: lessons learned.

Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.

Proteolytic autodigestion: common tissue pathology in Shwachman-Diamond syndrome?

Human endogenous retrovirus K (HML-2) RNA and protein expression is a marker for human embryonic and induced pluripotent stem cells.

Development. A stem cell perspective on cellular engineering.

Lin28 enhances tissue repair by reprogramming cellular metabolism.

Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity.

Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs.

Lin28 sustains early renal progenitors and induces Wilms tumor.

Functional evaluation of ES-somatic cell hybrids in vitro and in vivo.

Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells.

Effect of developmental stage of HSC and recipient on transplant outcomes.

Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models.

Dissecting engineered cell types and enhancing cell fate conversion via CellNet.

CellNet: network biology applied to stem cell engineering.

Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.

The epithelial-mesenchymal transition factor SNAIL paradoxically enhances reprogramming.

A nontranscriptional role for Oct4 in the regulation of mitotic entry.

A comparison of non-integrating reprogramming methods.

Deriving blood stem cells from pluripotent stem cells for research and therapy.

Deconstructing transcriptional heterogeneity in pluripotent stem cells.

Defining cellular identity through network biology.

Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.

Metabolic switches linked to pluripotency and embryonic stem cell differentiation.

De novo generation of HSCs from somatic and pluripotent stem cell sources.

Biotechnology. A prudent path forward for genomic engineering and germline gene modification.