Corey Smith
Department of Physiology and Biophysics
Case Western Reserve University
Dr. Corey Smith earned his Bachelor's of Science in Science from the University of Wisconsin - Madison in Biocore/Zoology. During his undergraduate years, he worked in several laboratories on the University of Wisconsin campus, with the majority of time spent in the lab of Richard Burgess, Department of Oncology. Dr. Smith then enrolled in the Ph.D. program in Neuroscience at the University of Colorado Health Sciences Center (now University of Colorado - Denver Anschutz Medical Center). There, he studied with Dr. William J. Betz with a focus on evoked release of neurotransmitters. Dr. Smith then moved to the Max Planck Institute for Biophysical Chemistry, Department of Membrane Biophysics, in Göttingen Germany where he was a postdoctoral research fellow in the laboratory of Dr. Erwin Neher. Dr. Smith continued the study of evoked neurotransmitter release.
Dr. Smith established his independent research program at the Medical College of Georgia in 1998 in the department of Physiology and Endocrinology. His laboratory focused on the understanding of differential transmitter release under the sympatho-adrenal stress reflex. In the fall of 2000, Dr. Smith moved the laboratory to the department of Physiology and Biophysics at Case Western Reserve University. There, his lab continued the molecular and functional description of the mechanisms responsible for differential transmitter release as a function of stress activation in the adrenal medulla. In the fall of 2013, Dr. Smith joined the newly formed Bioelectronics Initiative formed by GlaxoSmithKline. It was in this organization Dr. Smith began a collaboration with Dr. Jeffrey Ardell focusing on the measure of sympathetic neurotransmitter in the heart under native autonomic regulation in healthy and infarcted hearts. This active collaboration formed a second major line of research in the Smith laboratory.
Physiological stimuli evoke two forms of endocytosis in bovine chromaffin cells.
The Journal of physiology Dec, 2001 | Pubmed ID: 11744761
Calcium dependence of action potential-induced endocytosis in chromaffin cells.
Pflügers Archiv : European journal of physiology Feb, 2003 | Pubmed ID: 12634923
Low frequency stimulation of mouse adrenal slices reveals a clathrin-independent, protein kinase C-mediated endocytic mechanism.
The Journal of physiology Dec, 2003 | Pubmed ID: 14500763
Action potential stimulation reveals an increased role for P/Q-calcium channel-dependent exocytosis in mouse adrenal tissue slices.
Archives of biochemistry and biophysics Mar, 2005 | Pubmed ID: 15680908
Adrenal chromaffin cells exhibit impaired granule trafficking in NCAM knockout mice.
Journal of neurophysiology Aug, 2005 | Pubmed ID: 15800072
Activity-dependent differential transmitter release in mouse adrenal chromaffin cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience Aug, 2005 | Pubmed ID: 16093382
Syntillas release Ca2+ at a site different from the microdomain where exocytosis occurs in mouse chromaffin cells.
Biophysical journal Mar, 2006 | Pubmed ID: 16387759
Physiological stimulation regulates the exocytic mode through calcium activation of protein kinase C in mouse chromaffin cells.
The Biochemical journal Oct, 2006 | Pubmed ID: 16784416
Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2006 | Pubmed ID: 17050729
Increased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C.
The Journal of physiology Oct, 2007 | Pubmed ID: 17702812
Matching native electrical stimulation by graded chemical stimulation in isolated mouse adrenal chromaffin cells.
Journal of neuroscience methods Nov, 2007 | Pubmed ID: 17714791
Myosin II activation and actin reorganization regulate the mode of quantal exocytosis in mouse adrenal chromaffin cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2008 | Pubmed ID: 18434525
Dynamin I plays dual roles in the activity-dependent shift in exocytic mode in mouse adrenal chromaffin cells.
Archives of biochemistry and biophysics Sep, 2008 | Pubmed ID: 18492483
Cortical F-actin, the exocytic mode, and neuropeptide release in mouse chromaffin cells is regulated by myristoylated alanine-rich C-kinase substrate and myosin II.
Molecular biology of the cell Jul, 2009 | Pubmed ID: 19420137
PACAP regulates immediate catecholamine release from adrenal chromaffin cells in an activity-dependent manner through a protein kinase C-dependent pathway.
Journal of neurochemistry Aug, 2009 | Pubmed ID: 19508428
Enhanced dense core granule function and adrenal hypersecretion in a mouse model of Rett syndrome.
The European journal of neuroscience Aug, 2009 | Pubmed ID: 19674087
Neonatal intermittent hypoxia impairs neuronal nicotinic receptor expression and function in adrenal chromaffin cells.
American journal of physiology. Cell physiology Aug, 2010 | Pubmed ID: 20664070
Dynamin and myosin regulate differential exocytosis from mouse adrenal chromaffin cells.
Cellular and molecular neurobiology Nov, 2010 | Pubmed ID: 21061163
Pituitary adenylate cyclase-activating peptide (PACAP) recruits low voltage-activated T-type calcium influx under acute sympathetic stimulation in mouse adrenal chromaffin cells.
The Journal of biological chemistry Dec, 2011 | Pubmed ID: 22009744
Reduced calcium current density in female versus male mouse adrenal chromaffin cells in situ.
Cell calcium Sep-Oct, 2012 | Pubmed ID: 22551621
Pituitary adenylate cyclase-activating peptide enhances electrical coupling in the mouse adrenal medulla.
American journal of physiology. Cell physiology Aug, 2012 | Pubmed ID: 22592408
Is PACAP the major neurotransmitter for stress transduction at the adrenomedullary synapse?
Journal of molecular neuroscience : MN Oct, 2012 | Pubmed ID: 22610912
Activity-dependent fusion pore expansion regulated by a calcineurin-dependent dynamin-syndapin pathway in mouse adrenal chromaffin cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2012 | Pubmed ID: 22836276
Syndapin 3 modulates fusion pore expansion in mouse neuroendocrine chromaffin cells.
American journal of physiology. Cell physiology May, 2014 | Pubmed ID: 24500282
Spatial and activity-dependent catecholamine release in rat adrenal medulla under native neuronal stimulation.
Physiological reports 09, 2016 | Pubmed ID: 27597763
PACAP signaling in stress: insights from the chromaffin cell.
Pflugers Archiv : European journal of physiology 01, 2018 | Pubmed ID: 28965274
Lung-injury depresses glutamatergic synaptic transmission in the nucleus tractus solitarii via discrete age-dependent mechanisms in neonatal rats.
Brain, behavior, and immunity 05, 2018 | Pubmed ID: 29601943
Peripheral-to-central immune communication at the area postrema glial-barrier following bleomycin-induced sterile lung injury in adult rats.
Brain, behavior, and immunity 07, 2020 | Pubmed ID: 32097765
Fast in vivo detection of myocardial norepinephrine levels in the beating porcine heart.
American journal of physiology. Heart and circulatory physiology 05, 2020 | Pubmed ID: 32216617
Rapid measurement of cardiac neuropeptide dynamics by capacitive immunoprobe in the porcine heart.
American journal of physiology. Heart and circulatory physiology 01, 2021 | Pubmed ID: 33095651
Scalable and reversible axonal neuromodulation of the sympathetic chain for cardiac control.
American journal of physiology. Heart and circulatory physiology 01, 2022 | Pubmed ID: 34860595
JoVE Hakkında
Telif Hakkı © 2020 MyJove Corporation. Tüm hakları saklıdır