John A. Wemmie

Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).

Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons.

The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.

cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.

Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning.

Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1.

Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons.

Stimulation of Posterior Thalamic Nuclei Induces Photophobic Behavior in Mice.

Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior.

Impaired motor performance and learning in glia maturation factor-knockout mice.

Stomatin modulates gating of acid-sensing ion channels.

Functional correction of CNS phenotypes in a lysosomal storage disease model using adeno-associated virus type 4 vectors.

Acid-sensing ion channels: advances, questions and therapeutic opportunities.

Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines.

Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit.

Seizure termination by acidosis depends on ASIC1a.

The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction.

Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses.

Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits.

Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior.

Stereotactic atlas-based depth electrode localization in the human amygdala.

Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine.

Acid-sensing ion channels: A new target for pain and CNS diseases.

The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior.

ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury.

Amygdala volume correlates positively with fearfulness in normal healthy girls.

Neonatal leptin administration alters regional brain volumes and blocks neonatal growth restriction-induced behavioral and cardiovascular dysfunction in male mice.

Histologic examination of the eye of acid-sensing ion channel 1a knockout mice.

Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice.

Neurobiology of panic and pH chemosensation in the brain.

Detecting activity-evoked pH changes in human brain.

Fear and panic in humans with bilateral amygdala damage.

Acid-sensing ion channels in pain and disease.

Functional t1ρ imaging in panic disorder.

Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli.

PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.

Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice.

Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis.

Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity.

Drug abuse and the simplest neurotransmitter.

The bed nucleus of the stria terminalis is critical for anxiety-related behavior evoked by CO2 and acidosis.

Rapid acquisition strategy for functional T1ρ mapping of the brain.

Brain abnormalities in bipolar disorder detected by quantitative T1ρ mapping.

Eccentricity mapping of the human visual cortex to evaluate temporal dynamics of functional T1ρ mapping.

Breathing Inhibited When Seizures Spread to the Amygdala and upon Amygdala Stimulation.

ASIC1A in the bed nucleus of the stria terminalis mediates TMT-evoked freezing.

Peripheral inflammation during abnormal mood states in bipolar I disorder.

Extinction of Cocaine Seeking Requires a Window of Infralimbic Pyramidal Neuron Activity after Unreinforced Lever Presses.

Transient acidosis while retrieving a fear-related memory enhances its lability.

Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states.

Relationship altered between functional T1ρ and BOLD signals in bipolar disorder.

Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping.

Attenuation of cocaine seeking in rats via enhancement of infralimbic cortical activity using stable step-function opsins.

A novel role for acid-sensing ion channels in Pavlovian reward conditioning.

Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine-seeking behavior.

Acid-Sensing Ion Channels: Novel Mediators of Cerebral Vascular Responses.

Loss of tau and Fyn reduces compensatory effects of MAP2 for tau and reveals a Fyn-independent effect of tau on calcium.

The amygdala differentially regulates defensive behaviors evoked by CO.

A human amygdala site that inhibits respiration and elicits apnea in pediatric epilepsy.

Comparison of TRho MRI, Glucose Metabolism, and Amyloid Burden Across the Cognitive Spectrum: A Pilot Study.

Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research.

A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment.

Post-acquisition CO Inhalation Enhances Fear Memory and Depends on ASIC1A.

Posterior Fossa Sub-Arachnoid Cysts Observed in Patients with Bipolar Disorder: a Retrospective Cohort Study.