Josef Penninger

Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney.

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes.

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.

Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection.

Human blood vessel organoids as a model of diabetic vasculopathy.

AIF-regulated oxidative phosphorylation supports lung cancer development.

Derivation and maintenance of mouse haploid embryonic stem cells.

Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.

Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy.

HACE1 deficiency leads to structural and functional neurodevelopmental defects.

Generation of blood vessel organoids from human pluripotent stem cells.

Improved Sensitivity in Low-Input Proteomics Using Micropillar Array-Based Chromatography.

The Role of Iron Regulation in Immunometabolism and Immune-Related Disease.

Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice.

A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes.

CLP1 acts as the main RNA kinase in mice.

B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction.

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.

Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM2.

Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury.

RANKL and OPG and their influence on breast volume changes during pregnancy in healthy women.

Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth.

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.

HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases.

Identification of ALK in Thinness.

Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol.

Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells.

Sclerostin expression in trabecular bone is downregulated by osteoclasts.

Fibroblasts as a source of self-antigens for central immune tolerance.

Targeting the RANKL/RANK/OPG Axis for Cancer Therapy.

A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans.

Hepatocyte Mitogen-Activated Protein Kinase Kinase 7 Contributes to Restoration of the Liver Parenchyma Following Injury in Mice.

Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies.

MKK7 deficiency in mature neurons impairs parental behavior in mice.

The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection.

Human recombinant soluble ACE2 in severe COVID-19.

Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection.

JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality.

Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling.

Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution.

Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells.

RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy.

Heme Biosynthesis mRNA Expression Signature: Towards a Novel Prognostic Biomarker in Patients with Diffusely Infiltrating Gliomas.

HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner.

Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics.

The oxidoreductase PYROXD1 uses NAD(P) as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.

Ferritinophagy and ferroptosis in the management of metabolic diseases.

A critical relationship between bone and fat: the role of bone marrow adipose-derived RANKL in bone metabolism.

Modeling a human CLP1 mutation in mouse identifies an accumulation of tyrosine pre-tRNA fragments causing pontocerebellar hypoplasia type 10.

Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites.

Autophagy in major human diseases.

Development of a novel, pan-variant aerosol intervention for COVID-19.

Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants.

Erratum to: Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies.

PRDM12 Is Transcriptionally Active and Required for Nociceptor Function Throughout Life.

Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis.

The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains.

Comparative Proteome Signatures of Trace Samples by Multiplexed Data-Independent Acquisition.

ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury.

Author Correction: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis.

Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor.

Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19.

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology.

Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor function.

TSPAN6 is a suppressor of Ras-driven cancer.

Correction: TSPAN6 is a suppressor of Ras-driven cancer.

Adult T-cells impair neonatal cardiac regeneration.

Recalibrating vascular malformations and mechanotransduction by pharmacological intervention.

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells.

Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity.

Redirecting Imipramine against Bluetongue Virus Infection: Insights from a Genome-wide Haploid Screening Study.

Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells.

Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide.

Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants.

Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer.

Targeting glycans for CAR therapy: The advent of sweet CARs.

ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury.

FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder.

Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.

AIF Overexpression Aggravates Oxidative Stress in Neonatal Male Mice After Hypoxia-Ischemia Injury.

The impact of heme biosynthesis regulation on glioma aggressiveness: Correlations with diagnostic molecular markers.

A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo.

On the essentiality of the angiotensin converting enzyme 2 receptor for SARS-CoV-2 infection and the potential of soluble angiotensin converting enzyme 2 proteins as universal approach for variants causing COVID-19.

The HUSH complex controls brain architecture and protocadherin fidelity.

Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models.

RANKL and RANK in Cancer Therapy.

Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level.

Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells.

Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation.