School of Biomedical Engineering,
Life Sciences Institute,
Department of Medical Genetics
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Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney.
Human molecular genetics Sep, 2004 | Pubmed ID: 15254018
Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes.
Nature communications , 2013 | Pubmed ID: 23864022
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2014 | Pubmed ID: 24516159
HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.
Nature communications Mar, 2014 | Pubmed ID: 24614889
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy Jan, 2016 | Pubmed ID: 26799652
The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.
Cell reports May, 2016 | Pubmed ID: 27160902
Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection.
Nature microbiology Feb, 2019 | Pubmed ID: 30455472
Human blood vessel organoids as a model of diabetic vasculopathy.
Nature Jan, 2019 | Pubmed ID: 30651639
AIF-regulated oxidative phosphorylation supports lung cancer development.
Cell research Jul, 2019 | Pubmed ID: 31133695
Derivation and maintenance of mouse haploid embryonic stem cells.
Nature protocols Jul, 2019 | Pubmed ID: 31160788
Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2019 | Pubmed ID: 31189595
Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy.
EMBO molecular medicine Aug, 2019 | Pubmed ID: 31267692
HACE1 deficiency leads to structural and functional neurodevelopmental defects.
Neurology. Genetics Jun, 2019 | Pubmed ID: 31321300
Generation of blood vessel organoids from human pluripotent stem cells.
Nature protocols Nov, 2019 | Pubmed ID: 31554955
Improved Sensitivity in Low-Input Proteomics Using Micropillar Array-Based Chromatography.
Analytical chemistry Nov, 2019 | Pubmed ID: 31612716
The Role of Iron Regulation in Immunometabolism and Immune-Related Disease.
Frontiers in molecular biosciences , 2019 | Pubmed ID: 31824960
Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice.
Cell death & disease Jan, 2020 | Pubmed ID: 32001673
A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes.
Nature communications Feb, 2020 | Pubmed ID: 32029734
CLP1 acts as the main RNA kinase in mice.
Biochemical and biophysical research communications Feb, 2020 | Pubmed ID: 32081435
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction.
Nature communications Feb, 2020 | Pubmed ID: 32103002
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.
Intensive care medicine Apr, 2020 | Pubmed ID: 32125455
Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM2.
Biochemical and biophysical research communications May, 2020 | Pubmed ID: 32143824
Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Apr, 2020 | Pubmed ID: 32157739
RANKL and OPG and their influence on breast volume changes during pregnancy in healthy women.
Scientific reports Mar, 2020 | Pubmed ID: 32198488
Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth.
Frontiers in bioengineering and biotechnology , 2020 | Pubmed ID: 32211389
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.
Cell May, 2020 | Pubmed ID: 32333836
HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases.
Cancer research Jul, 2020 | Pubmed ID: 32366477
Identification of ALK in Thinness.
Cell Jun, 2020 | Pubmed ID: 32442405
Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol.
Communications biology Jul, 2020 | Pubmed ID: 32620833
Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells.
Emerging microbes & infections Dec, 2020 | Pubmed ID: 32691695
Sclerostin expression in trabecular bone is downregulated by osteoclasts.
Scientific reports Aug, 2020 | Pubmed ID: 32792620
Fibroblasts as a source of self-antigens for central immune tolerance.
Nature immunology Oct, 2020 | Pubmed ID: 32839611
Targeting the RANKL/RANK/OPG Axis for Cancer Therapy.
Frontiers in oncology , 2020 | Pubmed ID: 32850393
A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans.
The Journal of experimental medicine Jan, 2021 | Pubmed ID: 32930709
Hepatocyte Mitogen-Activated Protein Kinase Kinase 7 Contributes to Restoration of the Liver Parenchyma Following Injury in Mice.
Hepatology (Baltimore, Md.) Jun, 2021 | Pubmed ID: 32969030
Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Nov, 2021 | Pubmed ID: 32997739
MKK7 deficiency in mature neurons impairs parental behavior in mice.
Genes to cells : devoted to molecular & cellular mechanisms Jan, 2021 | Pubmed ID: 33098150
The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection.
Gastroenterology Jan, 2021 | Pubmed ID: 33130103
Human recombinant soluble ACE2 in severe COVID-19.
The Lancet. Respiratory medicine Nov, 2020 | Pubmed ID: 33131609
Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection.
EMBO molecular medicine Jan, 2021 | Pubmed ID: 33179852
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality.
Science advances Jan, 2021 | Pubmed ID: 33187978
Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling.
The EMBO journal Dec, 2020 | Pubmed ID: 33215740
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution.
Nature metabolism Dec, 2020 | Pubmed ID: 33288951
Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells.
Nature communications Dec, 2020 | Pubmed ID: 33303745
RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy.
Nature Jan, 2021 | Pubmed ID: 33361811
Heme Biosynthesis mRNA Expression Signature: Towards a Novel Prognostic Biomarker in Patients with Diffusely Infiltrating Gliomas.
Cancers Feb, 2021 | Pubmed ID: 33562253
HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner.
Oncogene Mar, 2021 | Pubmed ID: 33603169
Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics.
Pharmacology & therapeutics Sep, 2021 | Pubmed ID: 33823204
The oxidoreductase PYROXD1 uses NAD(P) as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Molecular cell Jun, 2021 | Pubmed ID: 33930333
Ferritinophagy and ferroptosis in the management of metabolic diseases.
Trends in endocrinology and metabolism: TEM Jul, 2021 | Pubmed ID: 34006412
A critical relationship between bone and fat: the role of bone marrow adipose-derived RANKL in bone metabolism.
EMBO reports Jul, 2021 | Pubmed ID: 34121307
Modeling a human CLP1 mutation in mouse identifies an accumulation of tyrosine pre-tRNA fragments causing pontocerebellar hypoplasia type 10.
Biochemical and biophysical research communications Sep, 2021 | Pubmed ID: 34273619
Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites.
The EMBO journal Oct, 2021 | Pubmed ID: 34375000
Autophagy in major human diseases.
The EMBO journal Oct, 2021 | Pubmed ID: 34459017
Development of a novel, pan-variant aerosol intervention for COVID-19.
bioRxiv : the preprint server for biology Sep, 2021 | Pubmed ID: 34545364
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants.
bioRxiv : the preprint server for biology Sep, 2021 | Pubmed ID: 34545368
Erratum to: Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Nov, 2021 | Pubmed ID: 34550333
PRDM12 Is Transcriptionally Active and Required for Nociceptor Function Throughout Life.
Frontiers in molecular neuroscience , 2021 | Pubmed ID: 34646120
Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis.
Nature methods 11, 2021 | Pubmed ID: 34725484
The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains.
iScience Nov, 2021 | Pubmed ID: 34755089
Comparative Proteome Signatures of Trace Samples by Multiplexed Data-Independent Acquisition.
Molecular & cellular proteomics : MCP Jan, 2022 | Pubmed ID: 34793982
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury.
Nature communications Nov, 2021 | Pubmed ID: 34815389
Author Correction: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis.
Nature methods Jan, 2022 | Pubmed ID: 34893784
Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor.
eLife Dec, 2021 | Pubmed ID: 34927585
Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19.
Frontiers in immunology , 2021 | Pubmed ID: 35003058
ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology.
eLife Jan, 2022 | Pubmed ID: 35023830
Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor function.
The FEBS journal Jun, 2022 | Pubmed ID: 35029322
TSPAN6 is a suppressor of Ras-driven cancer.
Oncogene Apr, 2022 | Pubmed ID: 35184157
Correction: TSPAN6 is a suppressor of Ras-driven cancer.
Oncogene Apr, 2022 | Pubmed ID: 35292775
Adult T-cells impair neonatal cardiac regeneration.
European heart journal Jul, 2022 | Pubmed ID: 35417553
Recalibrating vascular malformations and mechanotransduction by pharmacological intervention.
The Journal of clinical investigation Apr, 2022 | Pubmed ID: 35426368
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells.
Cell metabolism Jun, 2022 | Pubmed ID: 35561674
Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity.
Cell May, 2022 | Pubmed ID: 35623327
Redirecting Imipramine against Bluetongue Virus Infection: Insights from a Genome-wide Haploid Screening Study.
Pathogens (Basel, Switzerland) May, 2022 | Pubmed ID: 35631123
Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells.
Cellular and molecular life sciences : CMLS Jun, 2022 | Pubmed ID: 35661927
Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide.
Scientific reports Jun, 2022 | Pubmed ID: 35672347
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants.
EMBO molecular medicine Aug, 2022 | Pubmed ID: 35781796
Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer.
PloS one , 2022 | Pubmed ID: 35816490
Targeting glycans for CAR therapy: The advent of sweet CARs.
Molecular therapy : the journal of the American Society of Gene Therapy Sep, 2022 | Pubmed ID: 35821636
ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury.
PloS one , 2022 | Pubmed ID: 35867642
FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder.
EMBO molecular medicine Sep, 2022 | Pubmed ID: 35916241
Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.
American journal of respiratory and critical care medicine Jan, 2023 | Pubmed ID: 35926164
AIF Overexpression Aggravates Oxidative Stress in Neonatal Male Mice After Hypoxia-Ischemia Injury.
Molecular neurobiology Nov, 2022 | Pubmed ID: 35974295
The impact of heme biosynthesis regulation on glioma aggressiveness: Correlations with diagnostic molecular markers.
Frontiers in molecular neuroscience , 2022 | Pubmed ID: 36187350
A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo.
Cell reports. Medicine Oct, 2022 | Pubmed ID: 36195094
On the essentiality of the angiotensin converting enzyme 2 receptor for SARS-CoV-2 infection and the potential of soluble angiotensin converting enzyme 2 proteins as universal approach for variants causing COVID-19.
Clinical and translational medicine Oct, 2022 | Pubmed ID: 36229914
The HUSH complex controls brain architecture and protocadherin fidelity.
Science advances Nov, 2022 | Pubmed ID: 36332029
Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models.
Nature communications Nov, 2022 | Pubmed ID: 36443325
RANKL and RANK in Cancer Therapy.
Physiology (Bethesda, Md.) Dec, 2022 | Pubmed ID: 36473204
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level.
Nature communications Dec, 2022 | Pubmed ID: 36566234
Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells.
STAR protocols Dec, 2022 | Pubmed ID: 36595951
Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation.
Cell & bioscience Jan, 2023 | Pubmed ID: 36624495
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