Joseph M. Hyser

Sequence analysis of the VP4, VP6, VP7, and NSP4 gene products of the bovine rotavirus WC3.

Rotavirus viremia and extraintestinal viral infection in the neonatal rat model.

Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4.

Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin.

Rotavirus vaccines and pathogenesis: 2008.

Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity.

Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication.

Genetic divergence of rotavirus nonstructural protein 4 results in distinct serogroup-specific viroporin activity and intracellular punctate structure morphologies.

Rotavirus non-structural proteins: structure and function.

Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-β signaling is required for rotavirus replication.

Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity.

A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly.

Human enteroids: preclinical models of non-inflammatory diarrhea.

Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract.

Structural plasticity of the coiled-coil domain of rotavirus NSP4.

Use of genetically-encoded calcium indicators for live cell calcium imaging and localization in virus-infected cells.

Pathophysiological Consequences of Calcium-Conducting Viroporins.

The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel.

Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion.

Bifidobacterium dentium Fortifies the Intestinal Mucus Layer via Autophagy and Calcium Signaling Pathways.

Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum.

Recovirus NS1-2 Has Viroporin Activity That Induces Aberrant Cellular Calcium Signaling To Facilitate Virus Replication.

Generation of Recombinant Rotavirus Expressing NSP3-UnaG Fusion Protein by a Simplified Reverse Genetics System.

Discovery of a bacterial peptide as a modulator of GLP-1 and metabolic disease.

Human intestinal enteroids as a model of -induced enteritis.

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

Rotavirus infection induces glycan availability to promote ileum-specific changes in the microbiome aiding rotavirus virulence.

Human-Derived Bifidobacterium dentium Modulates the Mammalian Serotonergic System and Gut-Brain Axis.

Reuterin disrupts metabolism and pathogenicity through reactive oxygen species generation.

Enteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection.

Mucin-Degrading Microbes Release Monosaccharides That Chemoattract and Facilitate Colonization of the Human Intestinal Mucus Layer.

Rotavirus induces intercellular calcium waves through ADP signaling.

Bacteroides ovatus Promotes IL-22 Production and Reduces Trinitrobenzene Sulfonic Acid-Driven Colonic Inflammation.

Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation.

-derived y-glutamylcysteine suppresses ER-mediated goblet cell stress and reduces TNBS-driven colonic inflammation.

Gastrointestinal organoids in the study of viral infections.

Acute high-fat diet impairs macrophage-supported intestinal damage resolution.

A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis.

Distribution of P2Y and P2X purinergic receptor expression within the intestine.

Host IPR channels are dispensable for rotavirus Ca signaling but critical for intercellular Ca waves that prime uninfected cells for rapid virus spread.