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A Murine Model of Hyperlipidemia&#45;Induced Heart Failure with Preserved Ejection Fraction

The pathophysiology of heart failure with preserved ejection fraction (HFpEF) driven by lipotoxicity is incompletely understood. Given the urgent need for ...

University of Miami Leonard M. Miller School of Medicine

Coronavirus disease 2019 (COVID-19) has been primarily linked to respiratory complications, including acute respiratory distress syndrome (ARDS). However, several systemic manifestations of the disease may also occur. One of the emerging complications that is being increasingly reported in the literature is the hypercoagulable and intense inflammatory state in COVID-19 patients, which leads to venous and/or arterial thrombosis, vasospasm, and ischemia. Despite the recent advances in diagnostic and treatment modalities, the diagnosis and management of vascular ischemia in this patient population remain a challenge, resulting in increased morbidity and mortality. In this case report, we highlight the etiology and potential treatment of limb ischemia in COVID-19 patients.

Unilateral Limb Ischemia in a COVID-19 Patient: A Case Report.

Alport syndrome (AS) is caused by mutations in type IV collagen genes that typically target and compromise the integrity of basement membranes in kidney, ocular, and sensorineural cochlear tissues. Type IV and V collagens are also integral components of arterial walls, and whereas collagenopathies including AS are implicated in aortic disease, the incidence of aortic aneurysm in AS is unknown probably because of underreporting. Consequently, AS is not presently considered an independent risk factor for aortic aneurysm and more detailed case studies including histological evidence of basement membrane abnormalities are needed to determine such a possible linkage.

Qusai Alitter

Interdisciplinary Stem Cell Institute

University of Miami Leonard M. Miller School of Medicine

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

Qusai Alitter

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Interdisciplinary Stem Cell Institute

University of Miami Leonard M. Miller School of Medicine

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

Interdisciplinary Stem Cell Institute