Patrick M. Woster

Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells.

Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells.

Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities.

Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota.

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.

Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1.

Loss of Lysine-Specific Demethylase 1 (LSD1) suppresses growth and alters gene expression of human colon cancer cells in a p53 and DNA methyltransferase 1 (DNMT1) independent manner.

Polyamine-based small molecule epigenetic modulators.

Polyamines and cancer: implications for chemotherapy and chemoprevention.

The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.

Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites.

Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism.

P1 and P1' para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease.

Design of small molecule epigenetic modulators.

Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1.

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.

3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors.

Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites.

Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.

Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures.

Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group.

Epigenetics: Novel Therapeutics Targeting Epigenetics.

Antibacterial Diamines Targeting Bacterial Membranes.

Targeting polyamine metabolism for cancer therapy and prevention.

Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis.

Corrigendum to "Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures" [Bioorg. Med. Chem. 23 (2015) 1601-1612].

Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis.

Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies.

Polyamine catabolism and oxidative damage.

Novel Synthetic Polyamines Have Potent Antimalarial Activities and by Decreasing Intracellular Spermidine and Spermine Concentrations.

Citizenship in the World of Medicinal Chemistry: 25 Years as an ACSMEDI Volunteer.

Dual inhibitors of LSD1 and spermine oxidase.

Aldehyde dehydrogenase-2 activation by Alda-1 decreases necrosis and fibrosis after bile duct ligation in mice.

Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling.

Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease.

Inhibition of Polyamine Biosynthesis Using Difluoromethylornithine Acts as a Potent Immune Modulator and Displays Therapeutic Synergy With PD-1-blockade.

The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme.

Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice.

Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells.

Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation.

New Transmission-Selective Antimalarial Agents through Hit-to-Lead Optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic Acid Derivatives.

Identification and Characterization of Novel Small-Molecule SMOX Inhibitors.

Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma.

Stimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma.

Establishing New Isosexual Pairs in Adult Male Guinea Pigs () to Facilitate Social Housing.