Drug Discovery and Biomedical Sciences
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Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells.
Amino acids Feb, 2012 | Pubmed ID: 21805138
Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells.
Amino acids Feb, 2012 | Pubmed ID: 21814790
Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities.
Journal of medicinal chemistry Oct, 2011 | Pubmed ID: 21882831
Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota.
The Journal of biological chemistry Dec, 2011 | Pubmed ID: 22025614
Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.
Biochemical and biophysical research communications May, 2012 | Pubmed ID: 22469467
Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1.
Journal of medicinal chemistry Sep, 2012 | Pubmed ID: 22876979
Loss of Lysine-Specific Demethylase 1 (LSD1) suppresses growth and alters gene expression of human colon cancer cells in a p53 and DNA methyltransferase 1 (DNMT1) independent manner.
The Biochemical journal Oct, 2012 | Pubmed ID: 23072722
Polyamine-based small molecule epigenetic modulators.
MedChemComm , 2012 | Pubmed ID: 23293738
Polyamines and cancer: implications for chemotherapy and chemoprevention.
Expert reviews in molecular medicine Feb, 2013 | Pubmed ID: 23432971
The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.
Amino acids Mar, 2014 | Pubmed ID: 23508577
Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites.
Amino acids Jul, 2013 | Pubmed ID: 23884694
Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism.
Molecular cancer therapeutics Oct, 2013 | Pubmed ID: 23943804
P1 and P1' para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease.
Journal of molecular graphics & modelling Feb, 2014 | Pubmed ID: 24291501
Design of small molecule epigenetic modulators.
Bioorganic & medicinal chemistry letters Jan, 2014 | Pubmed ID: 24300735
Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1.
ACS medicinal chemistry letters Jan, 2014 | Pubmed ID: 24883177
Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.
Oncogene Jun, 2015 | Pubmed ID: 25174398
3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors.
MedChemComm Dec, 2014 | Pubmed ID: 25580204
Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites.
Bioorganic & medicinal chemistry Aug, 2015 | Pubmed ID: 25684422
Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.
The Journal of biological chemistry Apr, 2015 | Pubmed ID: 25713082
Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures.
Bioorganic & medicinal chemistry Apr, 2015 | Pubmed ID: 25725609
Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group.
MedChemComm Apr, 2015 | Pubmed ID: 26005563
Epigenetics: Novel Therapeutics Targeting Epigenetics.
Journal of medicinal chemistry Feb, 2016 | Pubmed ID: 26824165
Antibacterial Diamines Targeting Bacterial Membranes.
Journal of medicinal chemistry Apr, 2016 | Pubmed ID: 26964758
Targeting polyamine metabolism for cancer therapy and prevention.
The Biochemical journal Oct, 2016 | Pubmed ID: 27679855
Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis.
European journal of medicinal chemistry Mar, 2018 | Pubmed ID: 29459279
Corrigendum to "Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures" [Bioorg. Med. Chem. 23 (2015) 1601-1612].
Bioorganic & medicinal chemistry Jul, 2018 | Pubmed ID: 29859749
Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis.
Epigenetics , 2018 | Pubmed ID: 29927684
Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies.
PloS one , 2018 | Pubmed ID: 30138353
Polyamine catabolism and oxidative damage.
The Journal of biological chemistry Nov, 2018 | Pubmed ID: 30333229
Novel Synthetic Polyamines Have Potent Antimalarial Activities and by Decreasing Intracellular Spermidine and Spermine Concentrations.
Frontiers in cellular and infection microbiology , 2019 | Pubmed ID: 30838177
Citizenship in the World of Medicinal Chemistry: 25 Years as an ACSMEDI Volunteer.
ACS medicinal chemistry letters May, 2019 | Pubmed ID: 31097983
Dual inhibitors of LSD1 and spermine oxidase.
MedChemComm May, 2019 | Pubmed ID: 31191868
Aldehyde dehydrogenase-2 activation by Alda-1 decreases necrosis and fibrosis after bile duct ligation in mice.
Free radical biology & medicine Dec, 2019 | Pubmed ID: 31557514
Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling.
Oncogene May, 2020 | Pubmed ID: 32350444
Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease.
ACS omega Jun, 2020 | Pubmed ID: 32596612
Inhibition of Polyamine Biosynthesis Using Difluoromethylornithine Acts as a Potent Immune Modulator and Displays Therapeutic Synergy With PD-1-blockade.
Journal of immunotherapy (Hagerstown, Md. : 1997) Oct, 2021 | Pubmed ID: 34133404
The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme.
Cancer gene therapy Jul, 2022 | Pubmed ID: 34522028
Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice.
Autophagy Nov, 2022 | Pubmed ID: 35293288
Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Jun, 2022 | Pubmed ID: 35447542
Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation.
RSC advances Oct, 2021 | Pubmed ID: 35497564
New Transmission-Selective Antimalarial Agents through Hit-to-Lead Optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic Acid Derivatives.
Chembiochem : a European journal of chemical biology Nov, 2022 | Pubmed ID: 36106425
Identification and Characterization of Novel Small-Molecule SMOX Inhibitors.
Medical sciences (Basel, Switzerland) Aug, 2022 | Pubmed ID: 36135832
Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma.
European journal of medicinal chemistry Dec, 2022 | Pubmed ID: 36223680
Stimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma.
Chemical science Feb, 2023 | Pubmed ID: 36845935
Establishing New Isosexual Pairs in Adult Male Guinea Pigs () to Facilitate Social Housing.
Journal of the American Association for Laboratory Animal Science : JAALAS Mar, 2024 | Pubmed ID: 38262624
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