David A. Haake

Novel 45-kilodalton leptospiral protein that is processed to a 31-kilodalton growth-phase-regulated peripheral membrane protein.

Leptospirosis, water sports, and chemoprophylaxis.

Global analysis of outer membrane proteins from Leptospira interrogans serovar Lai.

Gastrointestinal microflora studies in late-onset autism.

Characterization of the leptospiral outer membrane and description of three novel leptospiral membrane proteins.

An improved immunohistochemical diagnostic technique for canine leptospirosis using antileptospiral antibodies on renal tissue.

LipL21 is a novel surface-exposed lipoprotein of pathogenic Leptospira species.

Pathogenic Leptospira species express surface-exposed proteins belonging to the bacterial immunoglobulin superfamily.

Molecular evolution and mosaicism of leptospiral outer membrane proteins involves horizontal DNA transfer.

Outer membrane proteins of pathogenic spirochetes.

Osmolarity, a key environmental signal controlling expression of leptospiral proteins LigA and LigB and the extracellular release of LigA.

Rapid, species-specific detection of uropathogen 16S rDNA and rRNA at ambient temperature by dot-blot hybridization and an electrochemical sensor array.

Diagnostic and therapeutic pitfalls associated with primaquine-tolerant Plasmodium vivax.

Leptospiral membrane proteins--variations on a theme?

Surfaceome of Leptospira spp.

Electrochemical molecular analysis without nucleic acid amplification.

Leptospirosis after recreational exposure to water in the Yaeyama islands, Japan.

LruA and LruB, novel lipoproteins of pathogenic Leptospira interrogans associated with equine recurrent uveitis.

Lipoprotein computational prediction in spirochaetal genomes.

Use of electrochemical DNA biosensors for rapid molecular identification of uropathogens in clinical urine specimens.

Molecular epidemiology of leptospirosis in the Amazon.

Effects of temperature on gene expression patterns in Leptospira interrogans serovar Lai as assessed by whole-genome microarrays.

LipL46 is a novel surface-exposed lipoprotein expressed during leptospiral dissemination in the mammalian host.

Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogen.

Leptospira immunoglobulin-like proteins as a serodiagnostic marker for acute leptospirosis.

Response of Leptospira interrogans to physiologic osmolarity: relevance in signaling the environment-to-host transition.

Development of an advanced electrochemical DNA biosensor for bacterial pathogen detection.

The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis.

Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement.

Early diagnosis of leptospirosis by immunoglobulin M immunoblot testing.

Rapid antimicrobial susceptibility determination of uropathogens in clinical urine specimens by use of ATP bioluminescence.

Optimal probe length and target location for electrochemical detection of selected uropathogens at ambient temperature.

Hamster model of leptospirosis.

Uropathogens and host characteristics.

Genetic diversity of the Leptospiral immunoglobulin-like (Lig) genes in pathogenic Leptospira spp.

An unsteady microfluidic T-form mixer perturbed by hydrodynamic pressure.

Leptospira interrogans stably infects zebrafish embryos, altering phagocyte behavior and homing to specific tissues.

A comprehensive approach to identification of surface-exposed, outer membrane-spanning proteins of Leptospira interrogans.

Multiplex pathogen identification for polymicrobial urinary tract infections using biosensor technology: a prospective clinical study.

Potentiometric detection of DNA hybridization using enzyme-induced metallization and a silver ion selective electrode.

Leptospira: a spirochaete with a hybrid outer membrane.

Transcriptional response of Leptospira interrogans to iron limitation and characterization of a PerR homolog.

The OmpL37 surface-exposed protein is expressed by pathogenic Leptospira during infection and binds skin and vascular elastin.

Ternary Surface Monolayers for Ultrasensitive (Zeptomole) Amperometric Detection of Nucleic Acid Hybridization without Signal Amplification.

Bacterial biofilm disruption using laser generated shockwaves.

Laser induced shockwaves on flexible polymers for treatment of bacterial biofilms.

Redox cycling amplified electrochemical detection of DNA hybridization: application to pathogen E. coli bacterial RNA.

The multifunctional LigB adhesin binds homeostatic proteins with potential roles in cutaneous infection by pathogenic Leptospira interrogans.

Ternary monolayers as DNA recognition interfaces for direct and sensitive electrochemical detection in untreated clinical samples.

Interactions of leptospira with environmental bacteria from surface water.

Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin.

Highly sensitive disposable nucleic acid biosensors for direct bioelectronic detection in raw biological samples.

Target-specific capture enhances sensitivity of electrochemical detection of bacterial pathogens.

Methylation and in vivo expression of the surface-exposed Leptospira interrogans outer membrane protein OmpL32.

A LigA three-domain region protects hamsters from lethal infection by Leptospira interrogans.

Three-Dimensional Structures of Pathogenic and Saprophytic Leptospira Revealed by Cryo-Electron Tomography.

Antibodies to a novel leptospiral protein, LruC, in the eye fluids and sera of horses with Leptospira-associated uveitis.

Multiple leptospiral sphingomyelinases (or are there?).

FlaA proteins in Leptospira interrogans are essential for motility and virulence but are not required for formation of the flagellum sheath.

Leptospiral outer membrane protein microarray, a novel approach to identification of host ligand-binding proteins.

Rapid antimicrobial susceptibility testing by sensitive detection of precursor rRNA using a novel electrochemical biosensing platform.

LipL32 Is a Subsurface Lipoprotein of Leptospira interrogans: presentation of new data and reevaluation of previous studies.