John Condeelis

Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex.

Interactions of elongation factor 1alpha with F-actin and beta-actin mRNA: implications for anchoring mRNA in cell protrusions.

A new strategy for caging proteins regulated by kinases.

Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling.

Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge.

Cell motility: insights from the backstage.

GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice.

Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouse.

Intravital imaging of cell movement in tumours.

Measurement of barbed ends, actin polymerization, and motility in live carcinoma cells after growth factor stimulation.

Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells.

Cofilin promotes actin polymerization and defines the direction of cell motility.

Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension.

Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation.

A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors.

Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells.

Breast cancer cells isolated by chemotaxis from primary tumors show increased survival and resistance to chemotherapy.

Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors.

A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin.

How and why does beta-actin mRNA target?

Cofilin takes the lead.

Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin.

Tumor cells caught in the act of invading: their strategy for enhanced cell motility.

The PCH family member MAYP/PSTPIP2 directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages.

Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy.

Localization of all seven messenger RNAs for the actin-polymerization nucleator Arp2/3 complex in the protrusions of fibroblasts.

Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop.

Description and characterization of a chamber for viewing and quantifying cancer cell chemotaxis.

Cell migration in tumors.

The great escape: when cancer cells hijack the genes for chemotaxis and motility.

Imaging of gene expression in living cells and tissues.

Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1.

Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis.

Macrophages: obligate partners for tumor cell migration, invasion, and metastasis.

Invadopodia and podosomes in tumor invasion.

The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors.

Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functional molecular study.

Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells.

ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo.

Regulation of the actin cytoskeleton in cancer cell migration and invasion.

Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland.

Visualization of mRNA translation in living cells.

Probing the microenvironment of mammary tumors using multiphoton microscopy.

Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis.

Moving in the right direction-nanoimaging in cancer cell motility and metastasis.

Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors.

Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines.

Imaging mRNA movement from transcription sites to translation sites.

Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors.

The cofilin pathway in breast cancer invasion and metastasis.

Cell motility and cytoskeletal regulation in invasion and metastasis.

The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration.

Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells.

ZBP1 enhances cell polarity and reduces chemotaxis.

Cofilin determines the migration behavior and turning frequency of metastatic cancer cells.

EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells.

Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods.

Imaging tumor cell movement in vivo.

RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.

WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells.

Mechanisms and cellular roles of local protein synthesis in mammalian cells.

Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo.

Intravital imaging of metastatic behavior through a mammary imaging window.

Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding.

A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis.

A common cofilin activity cycle in invasive tumor cells and inflammatory cells.

Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination.

N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells.

The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for phosphatidylinositol 3-kinase and Cdc42.

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation.

Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering.

In vivo assay for tumor cell invasion.

Stretching the timescale of intravital imaging in tumors.

The cofilin activity cycle in lamellipodia and invadopodia.

Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.

Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor.

Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors.

N-WASP has the ability to compensate for the loss of WASP in macrophage podosome formation and chemotaxis.

AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment.

Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes.

In vivo imaging in cancer.

Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models.

A new chemotaxis device for cell migration studies.

Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.

Metastasis: tumor cells becoming MENAcing.

Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors.

An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.

Visualization of actin polymerization in invasive structures of macrophages and carcinoma cells using photoconvertible β-actin-Dendra2 fusion proteins.

Imaging real-time gene expression in Mammalian cells with single-transcript resolution.

Imaging real-time gene expression in living yeast.

Imaging real-time gene expression in living systems with single-transcript resolution: image analysis of single mRNA transcripts.

Imaging Real-Time Gene Expression in Living Systems with Single-Transcript Resolution: Single mRNA Particle Tracking with ImageJ-Based Analysis.

Imaging real-time gene expression in living systems with single-transcript resolution: construct design and imaging system setup.

A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia.

Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM.

A temporal model of cofilin regulation and the early peak of actin barbed ends in invasive tumor cells.

Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion.

Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer.

Chemotaxis in cancer.

A photoswitchable orange-to-far-red fluorescent protein, PSmOrange.

An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.

Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging.

High-resolution multiphoton imaging of tumors in vivo.

The in vivo invasion assay: preparation and handling of collection needles.

Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway.

Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis.

Directed cell invasion and migration during metastasis.

Correlated Immunohistochemical and Cytological Assays for the Prediction of Hematogenous Dissemination of Breast Cancer.

Contribution of CXCL12 secretion to invasion of breast cancer cells.

Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration.

Time-lapsed, large-volume, high-resolution intravital imaging for tissue-wide analysis of single cell dynamics.

Black race and distant recurrence after neoadjuvant or adjuvant chemotherapy in breast cancer.

Tumor Microenvironment of Metastasis (TMEM) Doorways Are Restricted to the Blood Vessel Endothelium in Both Primary Breast Cancers and Their Lymph Node Metastases.

Intravital Imaging Techniques for Biomedical and Clinical Research.

Validation of an Automated Quantitative Digital Pathology Approach for Scoring TMEM, a Prognostic Biomarker for Metastasis.

The role of the tumor microenvironment in tumor cell intravasation and dissemination.

Hematogenous Dissemination of Breast Cancer Cells From Lymph Nodes Is Mediated by Tumor MicroEnvironment of Metastasis Doorways.

Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination.

Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells.

Combining TMEM Doorway Score and Mena Score Improves the Prediction of Distant Recurrence Risk in HR+/HER2- Breast Cancer Patients.

Racial disparity in distant recurrence-free survival in patients with localized breast cancer: A pooled analysis of National Surgical Adjuvant Breast and Bowel Project trials.

SWIP-a stabilized window for intravital imaging of the murine pancreas.

Assessment of MRI to estimate metastatic dissemination risk and prometastatic effects of chemotherapy.

Interleukin 4 Controls the Pro-Tumoral Role of Macrophages in Mammary Cancer Pulmonary Metastasis in Mice.

Intravital imaging to study cancer progression and metastasis.

Cooperative NF-κB and Notch1 signaling promotes macrophage-mediated MenaINV expression in breast cancer.

Macrophages Promote Tumor Cell Extravasation across an Endothelial Barrier through Thin Membranous Connections.

Racial disparity in tumor microenvironment and distant recurrence in residual breast cancer after neoadjuvant chemotherapy.