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Tianjin General Surgery Institute

2 ARTICLES PUBLISHED IN JoVE

Medicine

The Efficacy and Underlying Pathway Mechanisms of ShiDuGao Treatment for Anus Eczema Based on GEO Datasets and Network Pharmacology

Song Wang^*1,2,3, Wanyi Xiao^*1,2, Anqi He^1,2, Jinyan Jia^1,2, Gang Liu^1,2

¹Department of General Surgery, Tianjin Medical University General Hospital, ²Tianjin General Surgery Institute, ³Department of General Surgery, Zibo Municipal Hospital

This investigative effort sought to elucidate the mechanism of topical drug administration using a synergistic integration of network pharmacology and gene expression omnibus (GEO) datasets. This article evaluated the feasibility, target, and mechanism of ShiDuGao (SDG) in treating anus eczema.

Medicine

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

Anqi He^*1,2, Song Wang^*1,2,3, Kaiyu Li^1,2, Baosong Li^1,2,4, Wanyi Xiao^1,2, Gang Liu^1,2

¹Department of General Surgery, Tianjin Medical University General Hospital, ²Tianjin General Surgery Institute, ³Department of General Surgery, Zibo Municipal Hospital, ⁴Department of General Surgery, Binzhou Medical University Hospital

This protocol describes the method for establishing a rat model of pouchitis. The ileal pouch model was created by performing ileal pouch-anal anastomosis (IPAA) surgery using microsurgical techniques. After the surgery, the rat was treated with 4% dextran sulfate sodium (DSS) for 4 days.