A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal DiseaseVincent Law 1,2, Margi Baldwin 3, Ganesan Ramamoorthi 4, Krithika Kodumudi 4, Nam Tran 1, Inna Smalley 5, Derek Duckett 6, Pawel Kalinski 7, Brian Czerniecki 4, Keiran S. M. Smalley 2, Peter A. Forsyth 1,2
1Department of Neuro-Oncology, H. Lee Moffitt Cancer Center & Research Institute, 2Department of Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, 3Department of Comparative Medicine, University of South Florida, 4Department of Breast Oncology, H. Lee Moffitt Cancer Center & Research Institute, 5Department of Cancer Physiology, H. Lee Moffitt Cancer Center & Research Institute, 6Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, 7Department of Medical Oncology, Roswell Park Comprehensive Cancer Center
Here, we describe a murine xenograft model that functionally resembles an Ommaya reservoir in patients. We developed the Murine Ommaya to study novel therapeutics for the universally fatal leptomeningeal disease.
