Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker DiscoveryJia Fan 1,2, James W. Gallagher 1, Hung-Jen Wu 1, Matthew G. Landry 1, Jason Sakamoto 1, Mauro Ferrari 1, Ye Hu 1
1Department of Nanomedicine, The Methodist Hospital Research Institute, 2CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology
We developed a technology based on mesoporous silica thin film for the selective recovery of low molecular weight proteins and peptides from human serum. The physico-chemical properties of our mesoporous chips were finely tuned to provide substantial control in peptide enrichment and consequently profile the serum proteome for diagnostic purposes.
