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National center for nanoscience and technology

1 ARTICLES PUBLISHED IN JoVE

Bioengineering

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Jia Fan^1,2, James W. Gallagher¹, Hung-Jen Wu¹, Matthew G. Landry¹, Jason Sakamoto¹, Mauro Ferrari¹, Ye Hu¹

¹Department of Nanomedicine, The Methodist Hospital Research Institute, ²CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology

We developed a technology based on mesoporous silica thin film for the selective recovery of low molecular weight proteins and peptides from human serum. The physico-chemical properties of our mesoporous chips were finely tuned to provide substantial control in peptide enrichment and consequently profile the serum proteome for diagnostic purposes.