National Hospital for Neurology and Neurosurgery

3 ARTICLES PUBLISHED IN JoVE

Medicine

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Mark Nowell¹, Roman Rodionov¹, Gergely Zombori², Rachel Sparks², Michele Rizzi¹, Sebastien Ourselin², Anna Miserocchi³, Andrew McEvoy³, John Duncan¹

¹Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, ²Center of Medical Imaging and Computing, UCL, ³Department of Neurosurgery, National Hospital for Neurology and Neurosurgery

We describe the steps to use our custom designed software for image integration, visualization and planning in epilepsy surgery.

Bioengineering

Patient-Specific Polyvinyl Alcohol Phantom Fabrication with Ultrasound and X-Ray Contrast for Brain Tumor Surgery Planning

Eleanor C. Mackle^*1,2, Jonathan Shapey^*1,2,3,4, Efthymios Maneas^1,2, Shakeel R. Saeed^3,5,6, Robert Bradford³, Sebastien Ourselin⁴, Tom Vercauteren⁴, Adrien E. Desjardins^1,2

¹Wellcome / EPSRC Centre for Interventional and Surgical Sciences, University College London, ²Department of Medical Physics and Biomedical Engineering, University College London, ³Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, ⁴School of Biomedical Engineering & Imaging Sciences, King's College London, ⁵The Ear Institute, University College London, ⁶The Royal National Throat, Nose and Ear Hospital, London

This protocol describes the fabrication of a patient specific skull, brain and tumor phantom. It uses 3D printing to create molds, and polyvinyl alcohol (PVA-c) is used as the tissue mimicking material.

Neuroscience

Improving Outcomes in Anteromesial Temporal Lobe Resections - A Demonstration of Resecting the Temporal Piriform Cortex

Debayan Dasgupta^1,2, Lawrence P. Binding^1,3, Davide Giampiccolo^1,2,3,4, Roisin Finn², Stephen Wastling^5,6, Sjoerd B. Vos^3,6,7, Anna Miserocchi^1,2,4, Andrew W. McEvoy^1,2,4, John S. Duncan¹

¹Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, ²Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, ³Department of Computer Science, Centre for Medical Image Computing, University College London, ⁴Institute of Neuroscience, Cleveland Clinic London, ⁵Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, ⁶Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, ⁷Centre for Microscopy, Characterisation, and Analysis, The University of Western Australia

Here, we demonstrate an approach to intraoperative neurosurgical guidance in anteromesial temporal lobe resections, specifically highlighting the use of tractography and anatomical masks to aid safe resection of the temporal portion of the piriform cortex - an area increasingly regarded as a crucial surgical target in drug-resistant mesial temporal lobe epilepsy.