National Hospital for Neurology and Neurosurgery

3 ARTICLES PUBLISHED IN JoVE

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Medicine

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
Mark Nowell 1, Roman Rodionov 1, Gergely Zombori 2, Rachel Sparks 2, Michele Rizzi 1, Sebastien Ourselin 2, Anna Miserocchi 3, Andrew McEvoy 3, John Duncan 1
1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, 2Center of Medical Imaging and Computing, UCL, 3Department of Neurosurgery, National Hospital for Neurology and Neurosurgery

We describe the steps to use our custom designed software for image integration, visualization and planning in epilepsy surgery.

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Bioengineering

Patient-Specific Polyvinyl Alcohol Phantom Fabrication with Ultrasound and X-Ray Contrast for Brain Tumor Surgery Planning
Eleanor C. Mackle *1,2, Jonathan Shapey *1,2,3,4, Efthymios Maneas 1,2, Shakeel R. Saeed 3,5,6, Robert Bradford 3, Sebastien Ourselin 4, Tom Vercauteren 4, Adrien E. Desjardins 1,2
1Wellcome / EPSRC Centre for Interventional and Surgical Sciences, University College London, 2Department of Medical Physics and Biomedical Engineering, University College London, 3Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, 4School of Biomedical Engineering & Imaging Sciences, King's College London, 5The Ear Institute, University College London, 6The Royal National Throat, Nose and Ear Hospital, London

This protocol describes the fabrication of a patient specific skull, brain and tumor phantom. It uses 3D printing to create molds, and polyvinyl alcohol (PVA-c) is used as the tissue mimicking material.

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Neuroscience

Improving Outcomes in Anteromesial Temporal Lobe Resections - A Demonstration of Resecting the Temporal Piriform Cortex
Debayan Dasgupta 1,2, Lawrence P. Binding 1,3, Davide Giampiccolo 1,2,3,4, Roisin Finn 2, Stephen Wastling 5,6, Sjoerd B. Vos 3,6,7, Anna Miserocchi 1,2,4, Andrew W. McEvoy 1,2,4, John S. Duncan 1
1Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, 2Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, 3Department of Computer Science, Centre for Medical Image Computing, University College London, 4Institute of Neuroscience, Cleveland Clinic London, 5Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, 6Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, 7Centre for Microscopy, Characterisation, and Analysis, The University of Western Australia

Here, we demonstrate an approach to intraoperative neurosurgical guidance in anteromesial temporal lobe resections, specifically highlighting the use of tractography and anatomical masks to aid safe resection of the temporal portion of the piriform cortex - an area increasingly regarded as a crucial surgical target in drug-resistant mesial temporal lobe epilepsy.

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