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Guangdong Medical University

4 ARTICLES PUBLISHED IN JoVE

Cancer Research

Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles

Baozhen Zhang^*1, Mingbin Zheng^*2,3, Lintao Cai², Xiujun Fan¹

¹Laboratory for Reproductive Health, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS), ²Guangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS), ³Department of Chemistry, Guangdong Medical University

Here, we present a protocol for the synthesis of placental chondroitin sulfate A binding peptide (plCSA-BP)-conjugated lipid-polymer nanoparticles via single-step sonication and bioconjugate techniques. These particles constitute a novel tool for the targeted delivery of therapeutics to most human tumors and placental trophoblasts to treat cancers and placental disorders.

Medicine

Plasma Polishing as a New Polishing Option to Reduce the Surface Roughness of Porous Titanium Alloy for 3D Printing

Zhiwei Lin^*1,2, Lincong Luo^*3, Dongxin Lin^*4, Yuping Deng^4,5, Yang Yang⁴, Xuecheng Huang⁶, Tingrui Wu¹, Wenhua Huang^1,2,4

¹Orthopedic Center, Affiliated Hospital of Guangdong Medical University, ²The School of Basic Medical Sciences, Guangdong Medical University, ³The School of Basic Medical Sciences, Fujian Medical University, ⁴Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, ⁵Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, ⁶Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian)

Plasma polishing is a promising surface processing technology, especially suitable for 3D printing of porous titanium alloy workpieces. It can remove semi-molten powders and ablative oxide layers, thereby effectively reducing surface roughness and improving surface quality.

Behavior

Integration of Animal Behavioral Assessment and Convolutional Neural Network to Study Wasabi-Alcohol Taste-Smell Interaction

Hiu-Lok Ngan¹, Zenghua Qi², Hong Yan¹, Yuanyuan Song¹, Tao Wang^1,3, Zongwei Cai^1,2

¹State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, ²Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, ³Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University

This article describes a set of methods for measuring the suppressive ability of sniffing alcoholic beverages on the wasabi-elicited stinging sensation.

Medicine

Isolation and Characterization of Exosomes Derived from Mouse Spleen Tissues

Yue Luo^*1, Keyu Liu^*1, Dongling Ling², Ting Gu², Liangqing Zhang¹, Wenliang Chen^2,3

¹Department of Anesthesiology, the Second Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, ²Scientific Research Center, the Second Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, ³Medical Interdisciplinary Science Research Center of Western Guangdong, the Second Affiliated Hospital of Guangdong Medical University, Guangdong Medical University

Here, we present a protocol to isolate mouse spleen-derived exosomes using a combination of digestion with collagenase type I and ultracentrifugation.