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RISystem

3 ARTICLES PUBLISHED IN JoVE

Medicine

Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models

¹Institute of Health and Biomedical Innovation, Queensland University of Technology, ²RISystem AG

One constraint of preclinical research in the field of bone repair is the lack of experimental control over the local mechanical environment within a healing bone lesion. We report the design and use of an external fixator for bone repair with the ability to change fixator stiffness in vivo.

Medicine

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice

Tina Histing¹, Michael D. Menger², Tim Pohlemann¹, Romano Matthys³, Tobias Fritz¹, Patric Garcia¹, Moritz Klein¹

¹Department of Trauma, Hand and Reconstructive Surgery, Saarland University, ²Institute for Clinical & Experimental Surgery, Saarland University, ³RISystem AG

This protocol describes an osteosynthesis technique using an intramedullary locking nail for standardized fixation of femur osteotomies, which can be used to analyze normal and defective bone healing in mice.

Medicine

In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur

Melanie Haffner-Luntzer¹, Fabian Müller-Graf^1,4, Romano Matthys², Alireza Abaei³, René Jonas¹, Florian Gebhard⁴, Volker Rasche^*3, Anita Ignatius^*1

¹Institute of Orthopedic Research and Biomechanics, University Medical Center Ulm, ²RISystem, ³Core Facility Small Animal MRI, University Medical Center Ulm, ⁴Department of Traumatology, Hand-, Plastic-, and Reconstructive Surgery, University Medical Center Ulm

The evaluation of tissue development in the fracture callus during endochondral bone healing is essential to monitor the healing process. Here, we report the use of a magnetic resonance imaging (MRI)-compatible external fixator for the mouse femur to allow MRI scans during bone regeneration in mice.