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3 ARTICLES PUBLISHED IN JoVE

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Medicine

Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models
Vaida Glatt 1, Romano Matthys 2
1Institute of Health and Biomedical Innovation, Queensland University of Technology, 2RISystem AG

One constraint of preclinical research in the field of bone repair is the lack of experimental control over the local mechanical environment within a healing bone lesion. We report the design and use of an external fixator for bone repair with the ability to change fixator stiffness in vivo.

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Medicine

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice
Tina Histing 1, Michael D. Menger 2, Tim Pohlemann 1, Romano Matthys 3, Tobias Fritz 1, Patric Garcia 1, Moritz Klein 1
1Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 2Institute for Clinical & Experimental Surgery, Saarland University, 3RISystem AG

This protocol describes an osteosynthesis technique using an intramedullary locking nail for standardized fixation of femur osteotomies, which can be used to analyze normal and defective bone healing in mice.

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Medicine

In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur
Melanie Haffner-Luntzer 1, Fabian Müller-Graf 1,4, Romano Matthys 2, Alireza Abaei 3, René Jonas 1, Florian Gebhard 4, Volker Rasche *3, Anita Ignatius *1
1Institute of Orthopedic Research and Biomechanics, University Medical Center Ulm, 2RISystem, 3Core Facility Small Animal MRI, University Medical Center Ulm, 4Department of Traumatology, Hand-, Plastic-, and Reconstructive Surgery, University Medical Center Ulm

The evaluation of tissue development in the fracture callus during endochondral bone healing is essential to monitor the healing process. Here, we report the use of a magnetic resonance imaging (MRI)-compatible external fixator for the mouse femur to allow MRI scans during bone regeneration in mice.

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