Sorbonne Paris Cité
2 ARTICLES PUBLISHED IN JoVE
JoVE Journal
Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling
Laura Megrelis 1,2,3, Jérôme Delon 1,2,3
1Inserm U1016, Institut Cochin, 2Cnrs, UMR8104, 3Université Paris Descartes, Sorbonne Paris Cité
Chemokine signaling elicits marked alterations of cellular morphology and some important redistributions of intracellular proteins. Here, a rapid and detailed protocol is provided to study these events.
JoVE Journal
Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Audrey Courboulin 1, Chantal Kang 2, Olivier Baillard 3,4,5, Sebastien Bonnet 1, Pierre Bonnet 6
1Department of Medicine, Pulmonary Hypertension Research Group (CRIUCPQ), Laval University, 2Institut National de la Recherche Agronomique, 3Université Diderot Paris, Sorbonne Paris Cité, 4Hôpital Lariboisière, Physiologie clinique Explorations Fonctionnelles, 5INSERM U 965, 6Service de Cardiologie, Centre Hospitalier Universitaire Tours
Pulmonary hypertension is associated with a significant reduction in pulmonary artery pulsatility, contractility and elasticity, contributing to an increase in pulmonary artery pressure and pulmonary resistance. Using a hypoxic piglet model, this study demonstrated that improving pulmonary artery plasticity using a newly developed pulsatile catheter improves hypoxic pulmonary hypertension.
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