Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized RecordingsPatrick Burns 1, Hai Lun Liu 2, Shikha Kuthiala 2, Gilles Fecteau 1, André Desrochers 1, Lucien Daniel Durosier 2, Mingju Cao 2, Martin G. Frasch 2,3,4
1Département de sciences cliniques, CHUV, Université de Montréal, St-Hyacinthe, QC, 2Département d'obstetriques et de gynécologie, CHU Ste-Justine Research Centre, Université de Montréal, 3Département de neurosciences, CHU Ste-Justine Centre de recherche, Université de Montréal, 4Centre de recherche en reproduction animale (CRRA), Université de Montréal, St-Hyacinthe, QC
The chronically instrumented non-anesthetized fetal sheep model is used to study human fetal development in health and disease, because it permits surgical placement and maintenance of catheters and electrodes, repetitive blood sampling, substance injection, recording of bioelectrical activity, and in vivo imaging. We describe the procedures required to establish this model.
