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Cellular Biomedicine Group, California

2 ARTICLES PUBLISHED IN JoVE

Medicine

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Zhongwei Sun^1,2, Feng Li³, Xin Zhou³, Wen Wang^1,2

¹Cellular Biomedicine Group, Shanghai, ²Cellular Biomedicine Group, Cupertino, ³Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University

This study describes the successful generation of a new chronic obstructive pulmonary disease (COPD) animal model by repeatedly exposing mice to high concentrations of ozone.

Developmental Biology

In Vivo Tracking of Human Adipose-derived Mesenchymal Stem Cells in a Rat Knee Osteoarthritis Model with Fluorescent Lipophilic Membrane Dye

Meng Li^*1,2, Ming Hao^*1,2, Dong Jiang³, Yanxi Chen⁴, Wen Wang^1,2

¹Cellular Biomedicine Group, China, ²Cellular Biomedicine Group, California, ³Department of Orthopedics, Shanghai TCM-Integrated Hospital, ⁴Department of Orthopedics, Shanghai East Hospital, Tongji University

This protocol describes an efficient way to monitor the cell persistence and biodistribution of human adipose-derived mesenchymal stem cells (haMSCs) by far-red fluorescence labeling in a rat knee osteoarthritis (KOA) model via intra-articular (IA) injection.