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Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico

2 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Giulia Ercoli¹, Gianluca Lopez^1,2, Camilla Ciapponi^1,3, Chiara Corti^1,2, Luca Despini⁴, Donatella Gambini⁵, Letterio Runza¹, Concetta Blundo⁴, Amedeo Sciarra¹, Nicola Fusco^1,6

¹Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, ²School of Medicine, University of Milan, ³School of Biology, University of Pavia, ⁴Division of Breast Surgery, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, ⁵Division of Medical Oncology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, ⁶Department of Biomedical, Surgical, and Dental Sciences, University of Milan

Heterogeneous distribution of HER2-positive cells can be observed in a subset of breast cancers and generates clinical dilemmas. Here, we introduce a reliable and cost-effective protocol to define, quantify, and compare HER2 intra-tumor genetic heterogeneity in a large series of heterogeneously processed breast cancers.

Medicine

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Marco Invernizzi¹, Letterio Runza², Alessandro De Sire¹, Lorenzo Lippi¹, Concetta Blundo³, Donatella Gambini⁴, Renzo Boldorini^5,6, Stefano Ferrero^2,7, Nicola Fusco^2,7

¹Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont "A. Avogadro", ²Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, ³Division of Breast Surgery, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, ⁴Division of Medical Oncology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, ⁵Division of Pathology, Maggiore della Carità Hospital, ⁶Department of Health Sciences, University of Eastern Piedmont "A. Avogadro", ⁷Department of Biomedical, Surgical, and Dental Sciences, University of Milan

Breast cancer related lymphedema is frequent in breast cancer survivors, but there are not widely employed guidelines for its diagnosis and quantification. Here, we introduce a reliable and cost-effective protocol to define, quantify, and compare upper limb volume in breast cancer patients.