A Xenograft Mouse Model to Assess Efficacy of Therapeutic Agents for Human Acute LeukemiaChandrika Gowda *1, Charyguly Annageldiyev *2,3, Pavan Kumar Dhanyamraju 1, Morgann Klink 1, Sinisa Dovat 1, Mark Kester 4,5, Thomas P. Loughran, Jr 4,6, David Claxton 2,3, Arati Sharma 1,2,7
1Department of Pediatrics, Pennsylvania State University College of Medicine, 2Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, 3Departments of Medicine, Division of Hematology and Oncology, Pennsylvania State University College of Medicine, 4University of Virginia Cancer Center, 5nanoSTAR Institute, University of Virginia, 6Division of Hematology and Oncology, Department of Medicine, University of Virginia School of Medicine, 7Department of Pharmacology, Pennsylvania State University College of Medicine
Mouse (Mus Musculus) models are being widely used to develop xenografts using human leukemia cells. These models provide a comparable biological system to study drug efficacy, pharmacodynamics, and pharmacokinetics. Modeling acute myeloid leukemia in immunocompromised mice is described in detail using the U937 cell line xenograft as an example.
