Experimental Autoimmune Neuritis (EAN) Motor Function Testing and Clinical Scoring
4:11
Results: Representative Analysis of P0180-199 Peptide-induced EAN Pathology
5:59
Conclusion
Transkript
The overall goal of this procedure is to successfully induce Experimental Autoimmune Neuritis or EAN in a mouse model for the functional and pathological analysis of the disease process. The EAN model can be used to address key questions relating
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This report outlines a simple approach to successfully induce experimental autoimmune neuritis (EAN) using the myelin protein zero (P0)180-199 peptide in combination with Freund's complete adjuvant and pertussis toxin. We present a sophisticated paradigm capable of accurately assessing the extent of functional deficits and neuropathology that occur in this EAN.