Monitoring Receptor-β-arrestin 1 and 2 Interactions in HEK293 Cells
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Results: GLP-1r-β-arrestin 1 and 2 Orientation Screening and Interactions
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Conclusion
Transkript
This protocol has a high impact in the field of drug discovery and development, especially in the development of novel, first-in-class drugs with minimal side effects. The main advantage of this technique is that it can be applied to any GPCR syst
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GPCR-β-arrestin interactions are an emerging field in GPCR drug discovery. Accurate, precise and easy to set up methods are necessary to monitor such interactions in living systems. We show a structural complementation assay to monitor GPCR-β-arrestin interactions in real time living cells, and it can be extended to any GPCR.