Sign In

13.1 : Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse organisms.

Genome comparison can reveal three levels of evolutionary relationships. The first level provides deep insight into sequences and protein domains that are conserved across diverse groups of organisms, such as humans and fishes. The second level increases the resolution further to identify the unique DNA elements present in the closely related species, such as humans and chimpanzees. The third level with even higher data resolution distinguishes the genetic differences within a species, such as different variants and subtypes of an organism. This high-level resolution may identify mutations particular to individual microbial strains or clusters of infected cases, helping to track the disease outbreaks.

DNA sequencing tools

Several methods can be used to obtain the DNA sequence data required to deduce evolutionary relationships. Among them, whole-genome sequencing or WGS is a widely used technique. It provides high-resolution data extremely helpful to analyze mutations and conserved sequences among several organisms. It can also identify the cause of genetic disorders by comparing the DNA sequence of affected individuals to those of other unaffected subjects.

Data analysis tools

The data obtained by WGS or similar sequencing methods is analyzed by appropriate software tools to deduce evolutionary relationships. Molecular Evolutionary Genetics Analysis (MEGA) is one of the most widely used software tools. The programs present in the MEGA, such as assembly sequence alignment, building evolutionary trees, estimating genetic distances, and computation of evolutionary time trees, allow the users to curate and interpret the raw data obtained from sequencing techniques.

Tags
Genome ComparisonEvolutionary RelationshipsDNA SequenceConservation Of DomainsGenome Sequencing TechnologiesDiverse OrganismsProtein DomainsUnique DNA ElementsGenetic DifferencesVariants And SubtypesHigh resolution DataWhole genome Sequencing WGS

From Chapter 13:

article

Now Playing

13.1 : Evolutionary Relationships through Genome Comparisons

Genomes and Evolution

5.3K Views

article

13.2 : Genome Copying Errors

Genomes and Evolution

3.8K Views

article

13.3 : Phylogenetic Trees

Genomes and Evolution

5.1K Views

article

13.4 : Synteny and Evolution

Genomes and Evolution

3.0K Views

article

13.5 : Multi-species Conserved Sequences

Genomes and Evolution

3.6K Views

article

13.6 : Gene Duplication and Divergence

Genomes and Evolution

5.8K Views

article

13.7 : Exon Recombination

Genomes and Evolution

3.4K Views

article

13.8 : Comparing Copy Number Variations and SNPs

Genomes and Evolution

13.0K Views

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2025 MyJoVE Corporation. All rights reserved