Name: creation of reversible cholestatic rat model
Uploaded: 2011-05-21T17:00:00
Description: Watch this Scientific Journal Video about Creation of Reversible Cholestatic Rat Model at JoVE.com

1。大鼠胆道解剖平均胆管的直径和长度分别为1毫米和29毫米。幽门及十二指肠乳头之间的平均距离为28毫米。有两个主胰管，胆管开放 - 前管打开左侧和右侧打开后管。除了 ​​这些主要的管道，一些小导管，耗尽了所有3个部分胰腺，直接开到胆管 。6 2。技术所有的动物实验进行伦理研究的健康指引的国家机构的协议，是由?...

<ol>
	<li>Gouma, D. J., Roughneen, P. T., Kumar, S., Moody, F. G., Rowlands, B. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Changes+in+nutritional+status+associated+with+obstructive+jaundice+and+biliary+drainage+in+rats.">Changes in nutritional status associated with obstructive jaundice and biliary drainage in rats.</a> Am J Clin Nutr. 44, 362-369 (1986).</li><li>Ohtsuka, M., Miyazaki, M., Kondo, Y., Nakajima, N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Neutrophil-mediated+sinusoidal+endothelial+cell+injury+after+extensive+hepatectomy+in+cholestatic+rats.">Neutrophil-mediated sinusoidal endothelial cell injury after extensive hepatectomy in cholestatic rats.</a> Hepatology. 25, 636-641 (1997).</li><li>Abe, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Kupffer+cell-derived+interleukin+10+is+responsible+for+impaired+bacterial+clearance+in+bile+duct-ligated+mice.">Kupffer cell-derived interleukin 10 is responsible for impaired bacterial clearance in bile duct-ligated mice.</a> Hepatology. 40, 414-423 (2004).</li><li>Saiki, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Preoperative+internal+biliary+drainage+is+superior+to+external+biliary+drainage+in+liver+regeneration+and+function+after+hepatectomy+in+obstructive+jaundiced+rats.">Preoperative internal biliary drainage is superior to external biliary drainage in liver regeneration and function after hepatectomy in obstructive jaundiced rats.</a> Ann Surg. 230, 655-662 (1999).</li><li>Subhas, G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Protective+effect+of+methylprednisolone+on+warm+ischemia-reperfusion+injury+in+a+cholestatic+rat+liver.">Protective effect of methylprednisolone on warm ischemia-reperfusion injury in a cholestatic rat liver.</a> Am J Surg. 199, 377-380 (2010).</li><li>Kara, M. E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+anatomical+study+on+the+rat+pancreas+and+its+ducts+with+emphasis+on+the+surgical+approach.">The anatomical study on the rat pancreas and its ducts with emphasis on the surgical approach.</a> Ann Anat. 187, 105-112 (2005).</li><li>Ryan, C. J., Than, T., Blumgart, L. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Choledochoduodenostomy+in+the+rat+with+obstructive+jaundice.">Choledochoduodenostomy in the rat with obstructive jaundice.</a> J Surg Res. 23, 321-331 (1977).</li></ol>

胆汁淤积，导致无数的肠胃系统的变化。研究已经完成前瞻性的免疫系统和营养状况的变化。1-3胆汁淤积影响肝手术的成果。已经进行研究，以改善存在胆汁淤积肝手术的结果。4-5在医药和研究方面的改进，进一步的研究工作将胆汁淤积。因此，有必要有一个良好的胆汁淤积模型。老鼠作为实验动物是首选，因为它是现成的，容易处理，价格低廉和一个研究hepatopancreatobiliary系统?...

creation of reversible cholestatic rat model

胆汁淤积是一个常用的外科医生和肠胃遇到的临床状况。胆汁淤积可引起各种生理变化和影响的营养状况和手术结果。发生在肝脏和其他器官的病理生理变化的研究是非常重要的。胆汁淤积大鼠模型中的各种研究已经完成。 我们在我们最近的研究中使用一个可逆的胆汁淤积大鼠模型，甲基强的松龙在缺血再灌注损伤中的作用。已被描述为创造一个可逆的胆汁淤积模型的各种技术。创造一个可逆的胆汁淤积大鼠模型可以是具有挑战性的小尺寸和独特hepatopancreatobiliary解剖大鼠。此视频文章演示了一个可逆的胆汁淤积模型的创建。 这种模式可用于在不同的研究，如营养，生理，病理组织学和免疫学变化在胃肠道的变化，。这种模式也可以用于胆汁淤积和肝手术的各种治疗干预的影响。

Watch this Scientific Journal Video about Creation of Reversible Cholestatic Rat Model at JoVE.com

Creation of Reversible Cholestatic Rat Model

胆汁淤积是一个常用的外科医生和肠胃遇到的临床状况。创造一个可逆的胆汁淤积大鼠模型可以是具有挑战性的小尺寸和独特hepatopancreatobiliary解剖大鼠。此视频文章演示了一个可逆的胆汁淤积模型的创建。

可逆的胆汁淤积大鼠模型的建立

Cholestasis is a clinical condition commonly encountered by both surgeons and gastroenterologists. Cholestasis can cause various physiological changes and ...

Research

JoVE Journal

Medicine

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model

大鼠建立压力超负荷心肌肥厚模型在升主动脉缩窄

Ascending aortic constriction is the most common and successful surgical model for creating pressure overload induced cardiac hypertrophy and heart ...

科研

医学

The Helsinki Rat Microsurgical Sidewall Aneurysm Model

赫尔辛基鼠显微旁瘤模型

Experimental saccular aneurysm models are necessary for testing novel surgical and endovascular treatment options and devices before they are introduced ...

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

的不可逆和可逆单侧输尿管梗阻小鼠模型

Obstruction of the kidney may affect native or transplanted kidneys and results in kidney injury and scarring. Presented here is a model of obstructive ...

Demonstration of the Rat Ischemic Skin Wound Model

在大鼠缺血性皮肤创伤模型的演示

The propensity for chronic wounds in humans increases with ageing, disease conditions such as diabetes and impaired cardiovascular function, and ...

Creation of Abdominal Adhesions in Mice

小鼠腹腔粘连的创建

Abdominal adhesions consist of fibrotic tissue that forms in the peritoneal space in response to an inflammatory insult, typically surgery or ...

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model

创作和移植的糖尿病伤口愈合模型中脂肪源性干细胞 (ASC) 表

Artificial skin has achieved considerable therapeutic results in clinical practice. However, artificial skin treatments for wounds in diabetic patients ...

Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion

阻断外瓦萨血管灌注对腹主动脉瘤鼠模型的建立

The adventitial vasa vasorum (VV) provides oxygen and nourishment to the aortic wall. Hypoxia in the aortic wall can cause enlarged abdominal aortic ...

Isometric Contractility Measurement of the Mouse Mesenteric Artery Using Wire Myography

用线 Myography 测定小鼠肠系膜动脉的等轴收缩力

The wire myograph technique is used to assess the contractility of vascular smooth muscles in response to depolarization, GPCR agonists/inhibitors and ...

Creation of Colonic Anastomosis in Mice

小鼠结肠吻合术的建立

Intestinal anastomoses are commonly performed in both elective and emergent operations. Even so, anastomotic leaks are a highly feared complications of ...

A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice

小鼠中可逆硅油诱发眼部高血压模型

Elevated intraocular pressure (IOP) is a well-documented risk factor for glaucoma. Here we describe a novel, effective method for consistently inducing ...