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Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

DOI :

10.3791/3373-v

13:42 min

November 2nd, 2011

November 2nd, 2011

28,615 Views

1Molecular Foundry, Lawrence Berkeley National Laboratory

A simple and general manual peptoid synthesis method involving basic equipment and commercially available reagents is outlined, enabling peptoids to be easily synthesized in most laboratories. The synthesis, purification and characterization of an amphiphilic peptoid 36mer is described, as well as its self-assembly into highly-ordered nanosheets.

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Solid phase Submonomer Synthesis

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