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Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials

DOI :

10.3791/57908-v

June 25th, 2018

June 25th, 2018

7,764 Views

1Department of Pharmaceutical Sciences, University of Nebraska Medical Center

The synthesis of polyamine-based peptide amphiphiles (PPAs) is a significant challenge due to the presence of multiple amine nitrogens, which requires judicious use of protecting groups to mask these reactive functionalities. In this paper, we describe a facile method for the preparation of these new class of self-assembling molecules.

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Keywords Polyamine based Peptide Amphiphiles

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