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Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

DOI :

10.3791/3393-v

March 13th, 2012

March 13th, 2012

57,643 Views

1School of Medical Sciences, University of New South Wales

Due to the simplicity of surgery and the robust behavioural outcome, chronic constriction of the sciatic nerve is one of the pre-eminent animal models of neuropathic pain. Within 24 hrs following surgery, pain hypersensitivity is established and can be quantitatively measured using a von Frey aesthesiometer (mechanical test) and plantar analgesia meter (thermal test).

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Chronic Constriction

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