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Endothelin-1 Induced Middle Cerebral Artery Occlusion Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Rat

DOI :

10.3791/50014-v

February 16th, 2013

February 16th, 2013

19,444 Views

1Department of Neurosurgery, University of Florida , 2Department of Anatomical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran , 3Department of Physiology and Functional Genomics, University of Florida , 4Department of Neurology, University of Florida

Several animal models of cerebral ischemia have been developed to simulate the human condition of stroke. This protocol describes the endothelin-1 (ET-1) induced middle cerebral artery occlusion (MCAO) model for ischemic stroke in rats. In addition, important considerations, advantages, and shortcomings of this model are discussed.

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