Transient Bilateral Common Carotid Artery Occlusion (tBCCAO)
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Results: Analysis of Eyelid Drooping, HIF-1α Stabilization, Reactive Gliosis, Visual Dysfunction, and Change in Retinal Thickness After tBCCAO
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Conclusion
Transcript
The mouse model established with this protocol can be utilized to investigate the pathophysiology of ischemic retinopathies and for in vivo drug screening. The current method could reduce reliance on various surgical instruments and shorten operat
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Here, we describe a mouse model of retinal ischemia by transient bilateral common carotid artery occlusion using simple sutures and a clamp. This model can be useful for understanding the pathological mechanisms of retinal ischemia caused by cardiovascular abnormalities.