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A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects

DOI :

10.3791/50440-v

August 14th, 2013

August 14th, 2013

12,642 Views

1Department of Ophthalmology, Northwestern University, 2Department of Neurobiology, Northwestern University

Chronic ocular hypertension is induced using laser photocoagulation of the trabecular meshwork in mouse eyes. The intraocular pressure (IOP) is elevated for several months after laser treatment. The decrease of visual acuity and contrast sensitivity of experimental animals are monitored using the optomotor test.

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