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Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

DOI :

10.3791/50483-v

June 26th, 2013

June 26th, 2013

26,285 Views

1Department of Neurosciences, Research Institute for Biosciences, University of Mons

This paper presents a complete methodology to prepare and preserve in vitro acute hippocampal slices from adult mice. This protocol allows the recording of very stable long-lasting long-term potentiation (LTP) for more than 8 hours with a success rate of 95%.

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Hippocampal Mouse Slices

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