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Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

DOI :

10.3791/50840-v

December 18th, 2013

December 18th, 2013

5,920 Views

1Department of Life Sciences, National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev

To study the relationship between protein homeostasis, stress and aging, we monitored changes in protein folding by following protein dysfunction, protein localization in the cell and protein stability at the organismal, cellular and protein levels, using the genetically tractable metazoan Caenorhabditis elegans as a model system.

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